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Dual effect of verapamil on rat peritoneal mast cells: inhibition or induction of histamine release.
Braz J Med Biol Res. 1982 Oct; 15(4-5):269-73.BJ

Abstract

1. Verapamil (1.0 microM) inhibits histamine release from rat peritoneal mast cells induced by both compound 48/80 (Burroughs Wellcome), an external calcium-independent stimulant, and by protamine, an external calcium-dependent stimulant. 2. The inhibition was reversed by calcium in a concentration-dependent manner and thus seems to be related to the calcium-blocking action of verapamil. The inhibitory effect of 1.0 microM verapamil on protamine-induced histamine release in the presence of 0.5 mM calcium was 64%, and 32% in the presence of 2.0 mM calcium. 3. At concentrations of 0.1-1.0 mM, verapamil induces histamine release. The verapamil-induced release was independent of calcium at lower concentrations but at 1.0 mM, more release was observed in the absence of calcium. Histamine release induced by verapamil was blocked by temperature (2-4 degrees C) and by 2,4-dinitrophenol. Glucose (5 mM) reversed the effect of 2,4-dinitrophenol.

Authors

Lunardi LO
No affiliation info available
Vugman I
No affiliation info available

MeSH

AnimalsAscitic FluidCalciumFemaleHistamine ReleaseMaleMast CellsProtaminesRatsRats, Inbred StrainsVerapamilp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6189538

Citation

Lunardi, L O., and I Vugman. "Dual Effect of Verapamil On Rat Peritoneal Mast Cells: Inhibition or Induction of Histamine Release." Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, vol. 15, no. 4-5, 1982, pp. 269-73.
Lunardi LO, Vugman I. Dual effect of verapamil on rat peritoneal mast cells: inhibition or induction of histamine release. Braz J Med Biol Res. 1982;15(4-5):269-73.
Lunardi, L. O., & Vugman, I. (1982). Dual effect of verapamil on rat peritoneal mast cells: inhibition or induction of histamine release. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas, 15(4-5), 269-73.
Lunardi LO, Vugman I. Dual Effect of Verapamil On Rat Peritoneal Mast Cells: Inhibition or Induction of Histamine Release. Braz J Med Biol Res. 1982;15(4-5):269-73. PubMed PMID: 6189538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual effect of verapamil on rat peritoneal mast cells: inhibition or induction of histamine release. AU - Lunardi,L O, AU - Vugman,I, PY - 1982/10/1/pubmed PY - 1982/10/1/medline PY - 1982/10/1/entrez SP - 269 EP - 73 JF - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JO - Braz J Med Biol Res VL - 15 IS - 4-5 N2 - 1. Verapamil (1.0 microM) inhibits histamine release from rat peritoneal mast cells induced by both compound 48/80 (Burroughs Wellcome), an external calcium-independent stimulant, and by protamine, an external calcium-dependent stimulant. 2. The inhibition was reversed by calcium in a concentration-dependent manner and thus seems to be related to the calcium-blocking action of verapamil. The inhibitory effect of 1.0 microM verapamil on protamine-induced histamine release in the presence of 0.5 mM calcium was 64%, and 32% in the presence of 2.0 mM calcium. 3. At concentrations of 0.1-1.0 mM, verapamil induces histamine release. The verapamil-induced release was independent of calcium at lower concentrations but at 1.0 mM, more release was observed in the absence of calcium. Histamine release induced by verapamil was blocked by temperature (2-4 degrees C) and by 2,4-dinitrophenol. Glucose (5 mM) reversed the effect of 2,4-dinitrophenol. SN - 0100-879X UR - https://www.unboundmedicine.com/medline/citation/6189538/Dual_effect_of_verapamil_on_rat_peritoneal_mast_cells:_inhibition_or_induction_of_histamine_release_ DB - PRIME DP - Unbound Medicine ER -