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Effect of anti-allergic and cyclic AMP-active drugs on histamine secretion from rat mast cells treated with the novel calcium ionophore chlortetracycline.
Int Arch Allergy Appl Immunol. 1983; 71(4):352-6.IA

Abstract

The anti-allergic drugs disodium cromoglycate, doxantrazole and quercetin, and a number of compounds known to elevate intracellular levels of cyclic AMP, inhibited histamine secretion from rat peritoneal mast cells stimulated with the novel calcium ionophore, chlortetracycline. The potency of the compounds varied inversely with the concentration of ionophore. The activity of the drugs cannot be explained in terms of their postulated effect on the receptor-mediated activation of calcium channels in the mast cell membrane. Alternative mechanisms for their action are thus considered.

Authors

White JR
No affiliation info available
Pearce FL
No affiliation info available

MeSH

AnimalsBucladesineChlortetracyclineCromolyn SodiumFemaleFlavonoidsHistamine ReleaseMaleMast CellsPhosphodiesterase InhibitorsProstaglandins EQuercetinRatsRats, Inbred StrainsThioxanthenesXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6190762

Citation

White, J R., and F L. Pearce. "Effect of Anti-allergic and Cyclic AMP-active Drugs On Histamine Secretion From Rat Mast Cells Treated With the Novel Calcium Ionophore Chlortetracycline." International Archives of Allergy and Applied Immunology, vol. 71, no. 4, 1983, pp. 352-6.
White JR, Pearce FL. Effect of anti-allergic and cyclic AMP-active drugs on histamine secretion from rat mast cells treated with the novel calcium ionophore chlortetracycline. Int Arch Allergy Appl Immunol. 1983;71(4):352-6.
White, J. R., & Pearce, F. L. (1983). Effect of anti-allergic and cyclic AMP-active drugs on histamine secretion from rat mast cells treated with the novel calcium ionophore chlortetracycline. International Archives of Allergy and Applied Immunology, 71(4), 352-6.
White JR, Pearce FL. Effect of Anti-allergic and Cyclic AMP-active Drugs On Histamine Secretion From Rat Mast Cells Treated With the Novel Calcium Ionophore Chlortetracycline. Int Arch Allergy Appl Immunol. 1983;71(4):352-6. PubMed PMID: 6190762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of anti-allergic and cyclic AMP-active drugs on histamine secretion from rat mast cells treated with the novel calcium ionophore chlortetracycline. AU - White,J R, AU - Pearce,F L, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 352 EP - 6 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 71 IS - 4 N2 - The anti-allergic drugs disodium cromoglycate, doxantrazole and quercetin, and a number of compounds known to elevate intracellular levels of cyclic AMP, inhibited histamine secretion from rat peritoneal mast cells stimulated with the novel calcium ionophore, chlortetracycline. The potency of the compounds varied inversely with the concentration of ionophore. The activity of the drugs cannot be explained in terms of their postulated effect on the receptor-mediated activation of calcium channels in the mast cell membrane. Alternative mechanisms for their action are thus considered. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/6190762/Effect_of_anti_allergic_and_cyclic_AMP_active_drugs_on_histamine_secretion_from_rat_mast_cells_treated_with_the_novel_calcium_ionophore_chlortetracycline_ DB - PRIME DP - Unbound Medicine ER -