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Diphencyprone in the treatment of alopecia areata.
Acta Derm Venereol. 1983; 63(1):49-52.AD

Abstract

27 patients suffering from either extensive alopecia areata (n = 5) or alopecia totalis (n = 22) were treated topically with diphencyprone, a new potent contact allergen. The duration of treatment ranged from 4 to 17 months. Unilateral induction of hair growth after unilateral treatment was observed in 23 patients. A continuous response after continuous treatment has been observed so far in 18 of these patients. Thus, diphencyprone was found to be as effective as DNCB or squaric acid dibutylester in the treatment of alopecia areata. Unlike DNCB, diphencyprone is not mutagenic in the Ames test. Compared with squaric acid dibutylester, diphencyprone is more stable and thus more suitable for storage when dissolved in acetone. Further investigative evaluation of diphencyprone may show whether this drug is suitable for a more general use in the treatment of severe forms of alopecia areata.

Authors

Happle R
No affiliation info available
Hausen BM
No affiliation info available
Wiesner-Menzel L
No affiliation info available

MeSH

AdolescentAdultAlopeciaAlopecia AreataChemical PhenomenaChemistryCyclopropanesDermatitis, ContactFemaleHairHumansMaleMiddle AgedTime Factors

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

6191489

Citation

Happle, R, et al. "Diphencyprone in the Treatment of Alopecia Areata." Acta Dermato-venereologica, vol. 63, no. 1, 1983, pp. 49-52.
Happle R, Hausen BM, Wiesner-Menzel L. Diphencyprone in the treatment of alopecia areata. Acta Derm Venereol. 1983;63(1):49-52.
Happle, R., Hausen, B. M., & Wiesner-Menzel, L. (1983). Diphencyprone in the treatment of alopecia areata. Acta Dermato-venereologica, 63(1), 49-52.
Happle R, Hausen BM, Wiesner-Menzel L. Diphencyprone in the Treatment of Alopecia Areata. Acta Derm Venereol. 1983;63(1):49-52. PubMed PMID: 6191489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphencyprone in the treatment of alopecia areata. AU - Happle,R, AU - Hausen,B M, AU - Wiesner-Menzel,L, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 49 EP - 52 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 63 IS - 1 N2 - 27 patients suffering from either extensive alopecia areata (n = 5) or alopecia totalis (n = 22) were treated topically with diphencyprone, a new potent contact allergen. The duration of treatment ranged from 4 to 17 months. Unilateral induction of hair growth after unilateral treatment was observed in 23 patients. A continuous response after continuous treatment has been observed so far in 18 of these patients. Thus, diphencyprone was found to be as effective as DNCB or squaric acid dibutylester in the treatment of alopecia areata. Unlike DNCB, diphencyprone is not mutagenic in the Ames test. Compared with squaric acid dibutylester, diphencyprone is more stable and thus more suitable for storage when dissolved in acetone. Further investigative evaluation of diphencyprone may show whether this drug is suitable for a more general use in the treatment of severe forms of alopecia areata. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/6191489/Diphencyprone_in_the_treatment_of_alopecia_areata_ L2 - http://www.diseaseinfosearch.org/result/313 DB - PRIME DP - Unbound Medicine ER -