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Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs.
Acta Neurol Scand. 1983 Mar; 67(3):143-50.AN

Abstract

The effect of 2 central nervous system glycolipids (cerebroside and ganglioside) on the encephalitogenic activity of bovine myelin basic protein (MBP) was studied in guinea pigs. Mixing each of these glycolipids with MBP and injection of these mixtures in Freund's incomplete adjuvant (FIA) abrogated the resistance to encephalomyelitis upon challenge with MBP in Freund's complete adjuvant (FCA). Primary injection of these glycolipid-MBP mixtures in FCA diminished the clinical signs of experimental allergic encephalomyelitis (EAE) as compared to primary injection of MBP in FCA. Considering the amount of ganglioside needed to optimally induce these effects, this phenomenon seemed to be aspecific. However, with cerebroside, only minor quantities were sufficient, suggesting specific interaction with the basic protein. In several aspects, close correlation was found between cellular immune activity to MBP as measured by skin reactivity and the development of EAE.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6191512

Citation

Brinkman, C J., et al. "Influence of Cerebroside and Ganglioside On the Encephalitogenic Activity of Myelin Basic Protein in Guinea Pigs." Acta Neurologica Scandinavica, vol. 67, no. 3, 1983, pp. 143-50.
Brinkman CJ, ter Laak HJ, Hommes OR. Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs. Acta Neurol Scand. 1983;67(3):143-50.
Brinkman, C. J., ter Laak, H. J., & Hommes, O. R. (1983). Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs. Acta Neurologica Scandinavica, 67(3), 143-50.
Brinkman CJ, ter Laak HJ, Hommes OR. Influence of Cerebroside and Ganglioside On the Encephalitogenic Activity of Myelin Basic Protein in Guinea Pigs. Acta Neurol Scand. 1983;67(3):143-50. PubMed PMID: 6191512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs. AU - Brinkman,C J, AU - ter Laak,H J, AU - Hommes,O R, PY - 1983/3/1/pubmed PY - 1983/3/1/medline PY - 1983/3/1/entrez SP - 143 EP - 50 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 67 IS - 3 N2 - The effect of 2 central nervous system glycolipids (cerebroside and ganglioside) on the encephalitogenic activity of bovine myelin basic protein (MBP) was studied in guinea pigs. Mixing each of these glycolipids with MBP and injection of these mixtures in Freund's incomplete adjuvant (FIA) abrogated the resistance to encephalomyelitis upon challenge with MBP in Freund's complete adjuvant (FCA). Primary injection of these glycolipid-MBP mixtures in FCA diminished the clinical signs of experimental allergic encephalomyelitis (EAE) as compared to primary injection of MBP in FCA. Considering the amount of ganglioside needed to optimally induce these effects, this phenomenon seemed to be aspecific. However, with cerebroside, only minor quantities were sufficient, suggesting specific interaction with the basic protein. In several aspects, close correlation was found between cellular immune activity to MBP as measured by skin reactivity and the development of EAE. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/6191512/Influence_of_cerebroside_and_ganglioside_on_the_encephalitogenic_activity_of_myelin_basic_protein_in_guinea_pigs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=1983&volume=67&issue=3&spage=143 DB - PRIME DP - Unbound Medicine ER -