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Calcium antagonists and histamine secretion from rat peritoneal mast cells.
Agents Actions. 1983 Apr; 13(2-3):144-8.AA

Abstract

The calcium antagonists verapamil and nifedipine inhibited histamine release induced from rat peritoneal mast cells by a number of secretory stimuli. However, the concentrations required were much higher than those active in smooth muscle preparations. The inhibition was unaffected by elevated levels of external calcium and the drugs prevented release in the absence of added calcium. The novel calcium antagonist, PY 108-068, had no effect on histamine secretion from mast cells. These results suggest that calcium channels in the mastocyte may differ from those in smooth muscle and that at concentrations required to inhibit secretion, verapamil and nifedipine may have non-specific stabilizing effects on the mast cell membrane.

Authors

Ennis M
No affiliation info available
Ind PW
No affiliation info available
Pearce FL
No affiliation info available
Dollery CT
No affiliation info available

MeSH

AnimalsAscitic FluidCalciumCalcium Channel BlockersFemaleHistamine ReleaseIn Vitro TechniquesMaleMast CellsNifedipineRatsRats, Inbred StrainsVerapamil

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6191545

Citation

Ennis, M, et al. "Calcium Antagonists and Histamine Secretion From Rat Peritoneal Mast Cells." Agents and Actions, vol. 13, no. 2-3, 1983, pp. 144-8.
Ennis M, Ind PW, Pearce FL, et al. Calcium antagonists and histamine secretion from rat peritoneal mast cells. Agents Actions. 1983;13(2-3):144-8.
Ennis, M., Ind, P. W., Pearce, F. L., & Dollery, C. T. (1983). Calcium antagonists and histamine secretion from rat peritoneal mast cells. Agents and Actions, 13(2-3), 144-8.
Ennis M, et al. Calcium Antagonists and Histamine Secretion From Rat Peritoneal Mast Cells. Agents Actions. 1983;13(2-3):144-8. PubMed PMID: 6191545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium antagonists and histamine secretion from rat peritoneal mast cells. AU - Ennis,M, AU - Ind,P W, AU - Pearce,F L, AU - Dollery,C T, PY - 1983/4/1/pubmed PY - 1983/4/1/medline PY - 1983/4/1/entrez SP - 144 EP - 8 JF - Agents and actions JO - Agents Actions VL - 13 IS - 2-3 N2 - The calcium antagonists verapamil and nifedipine inhibited histamine release induced from rat peritoneal mast cells by a number of secretory stimuli. However, the concentrations required were much higher than those active in smooth muscle preparations. The inhibition was unaffected by elevated levels of external calcium and the drugs prevented release in the absence of added calcium. The novel calcium antagonist, PY 108-068, had no effect on histamine secretion from mast cells. These results suggest that calcium channels in the mastocyte may differ from those in smooth muscle and that at concentrations required to inhibit secretion, verapamil and nifedipine may have non-specific stabilizing effects on the mast cell membrane. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6191545/Calcium_antagonists_and_histamine_secretion_from_rat_peritoneal_mast_cells_ DB - PRIME DP - Unbound Medicine ER -