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Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45Ca uptake and histamine release in rat mast cells induced by various stimulating agents.
Int Arch Allergy Appl Immunol. 1983; 72(2):102-9.IA

Abstract

The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 micrograms/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine release than cromolyn sodium. In mast cells, nonimmunologically stimulated by concanavalin A, compound 48/80, and calcium ionophore A23187, nifedipine exerted considerable inhibitory effects on both 45Ca and histamine release.

Authors

Tanizaki Y
No affiliation info available
Akagi K
No affiliation info available
Lee KN
No affiliation info available
Townley RG
No affiliation info available

MeSH

AnimalsCalciumCalcium RadioisotopesConcanavalin ACromolyn SodiumFemaleHistamine ReleaseMaleMast CellsMethacholine CompoundsNifedipinePassive Cutaneous AnaphylaxisPyridinesRatsSerotoninSkin Testsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6192096

Citation

Tanizaki, Y, et al. "Inhibitory Effect of Nifedipine and Cromolyn Sodium On Skin Reactions and 45Ca Uptake and Histamine Release in Rat Mast Cells Induced By Various Stimulating Agents." International Archives of Allergy and Applied Immunology, vol. 72, no. 2, 1983, pp. 102-9.
Tanizaki Y, Akagi K, Lee KN, et al. Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45Ca uptake and histamine release in rat mast cells induced by various stimulating agents. Int Arch Allergy Appl Immunol. 1983;72(2):102-9.
Tanizaki, Y., Akagi, K., Lee, K. N., & Townley, R. G. (1983). Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45Ca uptake and histamine release in rat mast cells induced by various stimulating agents. International Archives of Allergy and Applied Immunology, 72(2), 102-9.
Tanizaki Y, et al. Inhibitory Effect of Nifedipine and Cromolyn Sodium On Skin Reactions and 45Ca Uptake and Histamine Release in Rat Mast Cells Induced By Various Stimulating Agents. Int Arch Allergy Appl Immunol. 1983;72(2):102-9. PubMed PMID: 6192096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45Ca uptake and histamine release in rat mast cells induced by various stimulating agents. AU - Tanizaki,Y, AU - Akagi,K, AU - Lee,K N, AU - Townley,R G, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 102 EP - 9 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 72 IS - 2 N2 - The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 micrograms/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine release than cromolyn sodium. In mast cells, nonimmunologically stimulated by concanavalin A, compound 48/80, and calcium ionophore A23187, nifedipine exerted considerable inhibitory effects on both 45Ca and histamine release. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/6192096/Inhibitory_effect_of_nifedipine_and_cromolyn_sodium_on_skin_reactions_and_45Ca_uptake_and_histamine_release_in_rat_mast_cells_induced_by_various_stimulating_agents_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6192096 DB - PRIME DP - Unbound Medicine ER -