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Immunocytochemical investigations of some human leukodystrophies.
Acta Neuropathol. 1983; 60(3-4):199-206.AN

Abstract

One case of each of the following human leukodystrophies was examined immunocytochemically with antisera against myelin basic protein (MBP), myelin associated glycoprotein (MAG) and gliofibrillary acidic protein (GFA): Metachromatic leukodystrophy (MLD), connatal adrenoleukodystrophy (ALD), sudanophilic leukodystrophy of the adult (SLD) and connatal Pelizaeus-Merzbacher disease (PMD). A case of canine globoid cell leukodystrophy (GLD) was also included under the assumption that this disease was the same in the dog as in man. It was shown that the storage process in MLD and GLD did not involve MBP or MAG and that the breakdown of myelin with the formation of fat granule cells containing droplets of neutral fat in ALD and SLS proceeds in a similar way as in experimental Wallerian degeneration. In PMD, MBP is present in the vicinity of axons not surrounded by a myelin sheath demonstrable with conventional means. The globoid cells of GLD could be demonstrated to be of non-astrocytic origin.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6193676

Citation

Ulrich, J, et al. "Immunocytochemical Investigations of some Human Leukodystrophies." Acta Neuropathologica, vol. 60, no. 3-4, 1983, pp. 199-206.
Ulrich J, Kohler R, Heitz PU, et al. Immunocytochemical investigations of some human leukodystrophies. Acta Neuropathol. 1983;60(3-4):199-206.
Ulrich, J., Kohler, R., Heitz, P. U., & Probst, A. (1983). Immunocytochemical investigations of some human leukodystrophies. Acta Neuropathologica, 60(3-4), 199-206.
Ulrich J, et al. Immunocytochemical Investigations of some Human Leukodystrophies. Acta Neuropathol. 1983;60(3-4):199-206. PubMed PMID: 6193676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunocytochemical investigations of some human leukodystrophies. AU - Ulrich,J, AU - Kohler,R, AU - Heitz,P U, AU - Probst,A, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 199 EP - 206 JF - Acta neuropathologica JO - Acta Neuropathol VL - 60 IS - 3-4 N2 - One case of each of the following human leukodystrophies was examined immunocytochemically with antisera against myelin basic protein (MBP), myelin associated glycoprotein (MAG) and gliofibrillary acidic protein (GFA): Metachromatic leukodystrophy (MLD), connatal adrenoleukodystrophy (ALD), sudanophilic leukodystrophy of the adult (SLD) and connatal Pelizaeus-Merzbacher disease (PMD). A case of canine globoid cell leukodystrophy (GLD) was also included under the assumption that this disease was the same in the dog as in man. It was shown that the storage process in MLD and GLD did not involve MBP or MAG and that the breakdown of myelin with the formation of fat granule cells containing droplets of neutral fat in ALD and SLS proceeds in a similar way as in experimental Wallerian degeneration. In PMD, MBP is present in the vicinity of axons not surrounded by a myelin sheath demonstrable with conventional means. The globoid cells of GLD could be demonstrated to be of non-astrocytic origin. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/6193676/Immunocytochemical_investigations_of_some_human_leukodystrophies_ L2 - https://antibodies.cancer.gov/detail/CPTC-ERCC2-1 DB - PRIME DP - Unbound Medicine ER -