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Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80.
Acta Pharmacol Toxicol (Copenh). 1983 Sep; 53(3):245-9.AP

Abstract

The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells.

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Publisher Full Text

Authors

Johansen T
No affiliation info available

MeSH

Adenosine TriphosphateAnimalsHistamine ReleaseIn Vitro TechniquesLactatesLactic AcidMaleMast CellsRatsRats, Inbred Strainsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6195889

Citation

Johansen, T. "Utilization of Adenosine Triphosphate in Rat Mast Cells During and After Secretion of Histamine in Response to Compound 48/80." Acta Pharmacologica Et Toxicologica, vol. 53, no. 3, 1983, pp. 245-9.
Johansen T. Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80. Acta Pharmacol Toxicol (Copenh). 1983;53(3):245-9.
Johansen, T. (1983). Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80. Acta Pharmacologica Et Toxicologica, 53(3), 245-9.
Johansen T. Utilization of Adenosine Triphosphate in Rat Mast Cells During and After Secretion of Histamine in Response to Compound 48/80. Acta Pharmacol Toxicol (Copenh). 1983;53(3):245-9. PubMed PMID: 6195889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Utilization of adenosine triphosphate in rat mast cells during and after secretion of histamine in response to compound 48/80. A1 - Johansen,T, PY - 1983/9/1/pubmed PY - 1983/9/1/medline PY - 1983/9/1/entrez SP - 245 EP - 9 JF - Acta pharmacologica et toxicologica JO - Acta Pharmacol Toxicol (Copenh) VL - 53 IS - 3 N2 - The adenosine triphosphate (ATP) content of rat mast cells and their lactate production were measured during and after secretion of histamine induced by compound 48/80. Antimycin A and oligomycin were used to block oxidative ATP synthesis, and 2-deoxyglucose (2-DG) was used to block glycolytic ATP synthesis. Histamine secretion was completed after 10 sec. exposure of the cells to compound 48/80. During that time period there was an increased ATP-utilization of 0.15 pmol/10(3) cells. After completion of the secretory process there seemed to be an enhanced utilization of ATP of 0.40 pmol/10(3) cells/min., which may be associated with recovery of the cells. SN - 0001-6683 UR - https://www.unboundmedicine.com/medline/citation/6195889/Utilization_of_adenosine_triphosphate_in_rat_mast_cells_during_and_after_secretion_of_histamine_in_response_to_compound_48/80_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6683&date=1983&volume=53&issue=3&spage=245 DB - PRIME DP - Unbound Medicine ER -