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Antibody responses to measles virus and canine distemper virus in multiple sclerosis.
Ann Neurol. 1983 Nov; 14(5):533-8.AN

Abstract

Age-matched serum and cerebrospinal fluid from 20 multiple sclerosis patients and 20 control patients with other neurological diseases were examined for antibodies to radiolabeled measles virus and canine distemper virus using an immunoprecipitation polyacrylamide gel technique. No evidence for reactivity to unique canine distemper virus-virion polypeptides in the multiple sclerosis group was obtained. Competitive binding experiments with cerebrospinal fluid using labeled and unlabeled viral antigens failed to detect preferences in binding of antibodies for canine distemper virus versus measles virus. Cerebrospinal fluid samples tested for antiviral immunoglobulin M activity using both measles and canine distemper viruses showed no activity. The results of this study failed to implicate canine distemper virus directly as a cause of multiple sclerosis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6197006

Citation

Krakowka, S, et al. "Antibody Responses to Measles Virus and Canine Distemper Virus in Multiple Sclerosis." Annals of Neurology, vol. 14, no. 5, 1983, pp. 533-8.
Krakowka S, Miele JA, Mathes LE, et al. Antibody responses to measles virus and canine distemper virus in multiple sclerosis. Ann Neurol. 1983;14(5):533-8.
Krakowka, S., Miele, J. A., Mathes, L. E., & Metzler, A. E. (1983). Antibody responses to measles virus and canine distemper virus in multiple sclerosis. Annals of Neurology, 14(5), 533-8.
Krakowka S, et al. Antibody Responses to Measles Virus and Canine Distemper Virus in Multiple Sclerosis. Ann Neurol. 1983;14(5):533-8. PubMed PMID: 6197006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody responses to measles virus and canine distemper virus in multiple sclerosis. AU - Krakowka,S, AU - Miele,J A, AU - Mathes,L E, AU - Metzler,A E, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 533 EP - 8 JF - Annals of neurology JO - Ann. Neurol. VL - 14 IS - 5 N2 - Age-matched serum and cerebrospinal fluid from 20 multiple sclerosis patients and 20 control patients with other neurological diseases were examined for antibodies to radiolabeled measles virus and canine distemper virus using an immunoprecipitation polyacrylamide gel technique. No evidence for reactivity to unique canine distemper virus-virion polypeptides in the multiple sclerosis group was obtained. Competitive binding experiments with cerebrospinal fluid using labeled and unlabeled viral antigens failed to detect preferences in binding of antibodies for canine distemper virus versus measles virus. Cerebrospinal fluid samples tested for antiviral immunoglobulin M activity using both measles and canine distemper viruses showed no activity. The results of this study failed to implicate canine distemper virus directly as a cause of multiple sclerosis. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/6197006/Antibody_responses_to_measles_virus_and_canine_distemper_virus_in_multiple_sclerosis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1983&volume=14&issue=5&spage=533 DB - PRIME DP - Unbound Medicine ER -