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Polyanionic inhibitors of calcium oxalate crystal agglomeration in urine.

Abstract

The excretions and relative potencies of various macromolecular inhibitors of the crystallisation of calcium oxalate (CaOx) were measured in the urines of idiopathic calcium stone-formers and normal subjects. The stone-formers excreted significantly less polyanionic macromolecules in their urine than did the normals, the difference being attributable to the lower excretions of glycosaminoglycans (GAGS), ribonucleic acid (RNA) and Tamm-Horsfall mucoprotein (THM), all of which are precipitable with alcian blue. The relative potencies of the various inhibitors measured under 'whole urine equivalent' conditions using a batch crystallisation system, showed that the order of inhibitory activity towards CaOx crystal agglomeration was RNA greater than GAGS greater than THM greater than pyrophosphate (PPi). This paralleled the order of ability of these inhibitors to produce a high negative zeta potential on the surface of CaOx crystals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6197713

Citation

Scurr, D S., et al. "Polyanionic Inhibitors of Calcium Oxalate Crystal Agglomeration in Urine." Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, vol. 20, 1983, pp. 440-4.
Scurr DS, Latif AB, Sergeant V, et al. Polyanionic inhibitors of calcium oxalate crystal agglomeration in urine. Proc Eur Dial Transplant Assoc. 1983;20:440-4.
Scurr, D. S., Latif, A. B., Sergeant, V., & Robertson, W. G. (1983). Polyanionic inhibitors of calcium oxalate crystal agglomeration in urine. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 20, 440-4.
Scurr DS, et al. Polyanionic Inhibitors of Calcium Oxalate Crystal Agglomeration in Urine. Proc Eur Dial Transplant Assoc. 1983;20:440-4. PubMed PMID: 6197713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyanionic inhibitors of calcium oxalate crystal agglomeration in urine. AU - Scurr,D S, AU - Latif,A B, AU - Sergeant,V, AU - Robertson,W G, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 440 EP - 4 JF - Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association JO - Proc Eur Dial Transplant Assoc VL - 20 N2 - The excretions and relative potencies of various macromolecular inhibitors of the crystallisation of calcium oxalate (CaOx) were measured in the urines of idiopathic calcium stone-formers and normal subjects. The stone-formers excreted significantly less polyanionic macromolecules in their urine than did the normals, the difference being attributable to the lower excretions of glycosaminoglycans (GAGS), ribonucleic acid (RNA) and Tamm-Horsfall mucoprotein (THM), all of which are precipitable with alcian blue. The relative potencies of the various inhibitors measured under 'whole urine equivalent' conditions using a batch crystallisation system, showed that the order of inhibitory activity towards CaOx crystal agglomeration was RNA greater than GAGS greater than THM greater than pyrophosphate (PPi). This paralleled the order of ability of these inhibitors to produce a high negative zeta potential on the surface of CaOx crystals. SN - 0071-2736 UR - https://www.unboundmedicine.com/medline/citation/6197713/Polyanionic_inhibitors_of_calcium_oxalate_crystal_agglomeration_in_urine_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6197713 DB - PRIME DP - Unbound Medicine ER -