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Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins.
Am J Surg Pathol 1984; 8(1):43-50AJ

Abstract

The histogenesis of extramammary Paget's disease has long remained unresolved and controversial. In an attempt to delineate the origin of the neoplastic cells in this disease, the immunoperoxidase localization of gross cystic disease fluid protein (GCDFP-15), a marker of apocrine epithelium, carcinoembryonic antigen (CEA), and keratin proteins, was determined for seven cases of extramammary Paget's disease (five vulvar, one anogenital, and one axillary). Immunoreactivity for GCDFP-15 was localized within Paget cells in six of our seven cases, including five cases from the vulva and one case from the axilla. CEA was present in the Paget cells in all seven cases. None of the Paget cells exhibited immunoreactivity for keratin proteins. Within normal skin, eccrine glands were immunoreactive for both keratin and CEA, whereas GCDFP-15 localized only to apocrine ducts and glands. Our findings strongly support an apocrine cell derivation for extramammary Paget's disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6198933

Citation

Mazoujian, G, et al. "Extramammary Paget's Disease--evidence for an Apocrine Origin. an Immunoperoxidase Study of Gross Cystic Disease Fluid Protein-15, Carcinoembryonic Antigen, and Keratin Proteins." The American Journal of Surgical Pathology, vol. 8, no. 1, 1984, pp. 43-50.
Mazoujian G, Pinkus GS, Haagensen DE. Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins. Am J Surg Pathol. 1984;8(1):43-50.
Mazoujian, G., Pinkus, G. S., & Haagensen, D. E. (1984). Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins. The American Journal of Surgical Pathology, 8(1), pp. 43-50.
Mazoujian G, Pinkus GS, Haagensen DE. Extramammary Paget's Disease--evidence for an Apocrine Origin. an Immunoperoxidase Study of Gross Cystic Disease Fluid Protein-15, Carcinoembryonic Antigen, and Keratin Proteins. Am J Surg Pathol. 1984;8(1):43-50. PubMed PMID: 6198933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extramammary Paget's disease--evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins. AU - Mazoujian,G, AU - Pinkus,G S, AU - Haagensen,D E,Jr PY - 1984/1/1/pubmed PY - 2001/3/28/medline PY - 1984/1/1/entrez SP - 43 EP - 50 JF - The American journal of surgical pathology JO - Am. J. Surg. Pathol. VL - 8 IS - 1 N2 - The histogenesis of extramammary Paget's disease has long remained unresolved and controversial. In an attempt to delineate the origin of the neoplastic cells in this disease, the immunoperoxidase localization of gross cystic disease fluid protein (GCDFP-15), a marker of apocrine epithelium, carcinoembryonic antigen (CEA), and keratin proteins, was determined for seven cases of extramammary Paget's disease (five vulvar, one anogenital, and one axillary). Immunoreactivity for GCDFP-15 was localized within Paget cells in six of our seven cases, including five cases from the vulva and one case from the axilla. CEA was present in the Paget cells in all seven cases. None of the Paget cells exhibited immunoreactivity for keratin proteins. Within normal skin, eccrine glands were immunoreactive for both keratin and CEA, whereas GCDFP-15 localized only to apocrine ducts and glands. Our findings strongly support an apocrine cell derivation for extramammary Paget's disease. SN - 0147-5185 UR - https://www.unboundmedicine.com/medline/citation/6198933/Extramammary_Paget's_disease__evidence_for_an_apocrine_origin__An_immunoperoxidase_study_of_gross_cystic_disease_fluid_protein_15_carcinoembryonic_antigen_and_keratin_proteins_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6198933.ui DB - PRIME DP - Unbound Medicine ER -