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Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat.
Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1880-2.PN

Abstract

In the rat, an intraseptal injection of the gamma-aminobutyric acid (GABA) agonist muscimol decreases the turnover rate of acetylcholine in the hippocampus and, during extinction of a food-reinforced lever-press response, increases extinction responding in a dose-dependent manner. Intraseptal beta-endorphin decreases the turnover rate of hippocampal acetylcholine through activation of septal GABAergic interneurons and increases extinction responding. On the other hand, intraseptal substance P, which decreases the turnover rate of hippocampal acetylcholine in a manner unrelated to septal GABAergic mechanisms, fails to increase extinction responding. The turnover rate of acetylcholine in various hippocampal regions after intraseptal injection of muscimol and substance P was also studied. Muscimol decreases the acetylcholine turnover rate only in the ventral hippocampus, whereas substance P decreases it only in the dorsal hippocampus. We hypothesize that a lowering in the cholinergic input to the ventral hippocampus is capable of increasing extinction responding, whereas a decrease in the input to the dorsal hippocampus is without such an effect. Hence, the cholinergic projections to the two hippocampal areas are modulated by different transmitter systems and have different physiological functions.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6200885

Citation

Blaker, W D., et al. "Behavioral and Neurochemical Differentiation of Specific Projections in the Septal-hippocampal Cholinergic Pathway of the Rat." Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 6, 1984, pp. 1880-2.
Blaker WD, Peruzzi G, Costa E. Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat. Proc Natl Acad Sci U S A. 1984;81(6):1880-2.
Blaker, W. D., Peruzzi, G., & Costa, E. (1984). Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat. Proceedings of the National Academy of Sciences of the United States of America, 81(6), 1880-2.
Blaker WD, Peruzzi G, Costa E. Behavioral and Neurochemical Differentiation of Specific Projections in the Septal-hippocampal Cholinergic Pathway of the Rat. Proc Natl Acad Sci U S A. 1984;81(6):1880-2. PubMed PMID: 6200885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat. AU - Blaker,W D, AU - Peruzzi,G, AU - Costa,E, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 1880 EP - 2 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 81 IS - 6 N2 - In the rat, an intraseptal injection of the gamma-aminobutyric acid (GABA) agonist muscimol decreases the turnover rate of acetylcholine in the hippocampus and, during extinction of a food-reinforced lever-press response, increases extinction responding in a dose-dependent manner. Intraseptal beta-endorphin decreases the turnover rate of hippocampal acetylcholine through activation of septal GABAergic interneurons and increases extinction responding. On the other hand, intraseptal substance P, which decreases the turnover rate of hippocampal acetylcholine in a manner unrelated to septal GABAergic mechanisms, fails to increase extinction responding. The turnover rate of acetylcholine in various hippocampal regions after intraseptal injection of muscimol and substance P was also studied. Muscimol decreases the acetylcholine turnover rate only in the ventral hippocampus, whereas substance P decreases it only in the dorsal hippocampus. We hypothesize that a lowering in the cholinergic input to the ventral hippocampus is capable of increasing extinction responding, whereas a decrease in the input to the dorsal hippocampus is without such an effect. Hence, the cholinergic projections to the two hippocampal areas are modulated by different transmitter systems and have different physiological functions. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/6200885/Behavioral_and_neurochemical_differentiation_of_specific_projections_in_the_septal_hippocampal_cholinergic_pathway_of_the_rat_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=6200885 DB - PRIME DP - Unbound Medicine ER -