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Effect of cyclic AMP, disodium cromoglycate and other anti-allergic drugs on histamine secretion from rat mast cells stimulated with the calcium ionophore ionomycin.
Agents Actions. 1984 Feb; 14(2):179-84.AA

Abstract

Cyclic AMP analogues and the anti-allergic drugs disodium cromoglycate, quercetin, doxantrazole and theophylline inhibited histamine secretion from rat peritoneal mast cells stimulated with the calcium ionophore ionomycin. The potency of the compounds varied inversely with the concentration of ionophore and with the period of incubation. The drugs were active in both the presence and absence of extracellular calcium. These results cannot be explained in terms of the postulated effect of the compounds on the receptor-mediated activation of calcium-channels. Alternative mechanisms for their action are thus considered.

Authors

Truneh A
No affiliation info available
Pearce FL
No affiliation info available

MeSH

AnimalsBronchodilator AgentsCalciumCromolyn SodiumCyclic AMPEthersFemaleHistamine H1 AntagonistsHistamine ReleaseIonomycinIonophoresKineticsMaleMast CellsQuercetinRatsRats, Inbred StrainsTheophyllineThioxanthenesXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6201056

Citation

Truneh, A, and F L. Pearce. "Effect of Cyclic AMP, Disodium Cromoglycate and Other Anti-allergic Drugs On Histamine Secretion From Rat Mast Cells Stimulated With the Calcium Ionophore Ionomycin." Agents and Actions, vol. 14, no. 2, 1984, pp. 179-84.
Truneh A, Pearce FL. Effect of cyclic AMP, disodium cromoglycate and other anti-allergic drugs on histamine secretion from rat mast cells stimulated with the calcium ionophore ionomycin. Agents Actions. 1984;14(2):179-84.
Truneh, A., & Pearce, F. L. (1984). Effect of cyclic AMP, disodium cromoglycate and other anti-allergic drugs on histamine secretion from rat mast cells stimulated with the calcium ionophore ionomycin. Agents and Actions, 14(2), 179-84.
Truneh A, Pearce FL. Effect of Cyclic AMP, Disodium Cromoglycate and Other Anti-allergic Drugs On Histamine Secretion From Rat Mast Cells Stimulated With the Calcium Ionophore Ionomycin. Agents Actions. 1984;14(2):179-84. PubMed PMID: 6201056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cyclic AMP, disodium cromoglycate and other anti-allergic drugs on histamine secretion from rat mast cells stimulated with the calcium ionophore ionomycin. AU - Truneh,A, AU - Pearce,F L, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 179 EP - 84 JF - Agents and actions JO - Agents Actions VL - 14 IS - 2 N2 - Cyclic AMP analogues and the anti-allergic drugs disodium cromoglycate, quercetin, doxantrazole and theophylline inhibited histamine secretion from rat peritoneal mast cells stimulated with the calcium ionophore ionomycin. The potency of the compounds varied inversely with the concentration of ionophore and with the period of incubation. The drugs were active in both the presence and absence of extracellular calcium. These results cannot be explained in terms of the postulated effect of the compounds on the receptor-mediated activation of calcium-channels. Alternative mechanisms for their action are thus considered. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6201056/Effect_of_cyclic_AMP_disodium_cromoglycate_and_other_anti_allergic_drugs_on_histamine_secretion_from_rat_mast_cells_stimulated_with_the_calcium_ionophore_ionomycin_ DB - PRIME DP - Unbound Medicine ER -