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[Studies in experimental animal models of the effect of ultraviolet radiation (UVC) on blood and isolated cell populations].

Abstract

The cellular and molecular basis of the therapeutically used effect of reinjected ultraviolet (UVC) irradiated blood is unknown. First approaches to that problem were made in this study by aid of model experiments. Neither the spontaneous degranulation nor the antigen-induced histamine release from rat connective tissue mast cells (in vivo) was influenced by the injection (i.v.) of ultraviolet irradiated blood or blood lymphocytes. By comparison of the effect of ultraviolet light on blood lymphocytes (number of dead cells, strength of chemoluminescence) after irradiation of the isolated cells and the unfractionated blood respectively, we could show that the strong light absorption within the blood sample prevents damage or functional alterations of the blood lymphocytes. The compound 48/80-induced histamine release from rat peritoneal mast cells can be completely inhibited by ultraviolet irradiation (0.6 mJ/cm2) without increasing the spontaneous histamine release.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6202599

Citation

Repke, H, et al. "[Studies in Experimental Animal Models of the Effect of Ultraviolet Radiation (UVC) On Blood and Isolated Cell Populations]." Folia Haematologica (Leipzig, Germany : 1928), vol. 111, no. 1, 1984, pp. 50-9.
Repke H, Scherf HP, Wiesner S. [Studies in experimental animal models of the effect of ultraviolet radiation (UVC) on blood and isolated cell populations]. Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(1):50-9.
Repke, H., Scherf, H. P., & Wiesner, S. (1984). [Studies in experimental animal models of the effect of ultraviolet radiation (UVC) on blood and isolated cell populations]. Folia Haematologica (Leipzig, Germany : 1928), 111(1), 50-9.
Repke H, Scherf HP, Wiesner S. [Studies in Experimental Animal Models of the Effect of Ultraviolet Radiation (UVC) On Blood and Isolated Cell Populations]. Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(1):50-9. PubMed PMID: 6202599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies in experimental animal models of the effect of ultraviolet radiation (UVC) on blood and isolated cell populations]. AU - Repke,H, AU - Scherf,H P, AU - Wiesner,S, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 50 EP - 9 JF - Folia haematologica (Leipzig, Germany : 1928) JO - Folia Haematol Int Mag Klin Morphol Blutforsch VL - 111 IS - 1 N2 - The cellular and molecular basis of the therapeutically used effect of reinjected ultraviolet (UVC) irradiated blood is unknown. First approaches to that problem were made in this study by aid of model experiments. Neither the spontaneous degranulation nor the antigen-induced histamine release from rat connective tissue mast cells (in vivo) was influenced by the injection (i.v.) of ultraviolet irradiated blood or blood lymphocytes. By comparison of the effect of ultraviolet light on blood lymphocytes (number of dead cells, strength of chemoluminescence) after irradiation of the isolated cells and the unfractionated blood respectively, we could show that the strong light absorption within the blood sample prevents damage or functional alterations of the blood lymphocytes. The compound 48/80-induced histamine release from rat peritoneal mast cells can be completely inhibited by ultraviolet irradiation (0.6 mJ/cm2) without increasing the spontaneous histamine release. SN - 0323-4347 UR - https://www.unboundmedicine.com/medline/citation/6202599/[Studies_in_experimental_animal_models_of_the_effect_of_ultraviolet_radiation__UVC__on_blood_and_isolated_cell_populations]_ L2 - https://medlineplus.gov/blood.html DB - PRIME DP - Unbound Medicine ER -