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Mouse T lymphocytes proliferative responses specific for human MHC products in mouse anti-human xenogeneic MLR.
J Immunol. 1984 Jun; 132(6):2820-9.JI

Abstract

It has been reported that human T cells recognize the polymorphism of murine Ia antigens in the human anti-mouse xenogeneic mixed lymphocyte reactions (MLR). In this study, murine T cell recognition of human Class II antigens of the major histocompatibility complex (MHC) was analyzed in mouse anti-human xenogeneic MLR responses. The xenoreactive murine T cell proliferative response was blocked by adding anti-HLA-DR monoclonal antibody to the xenogeneic MLR culture. The specificity of xenoreactive murine T cells was examined with regard to the secondary and tertiary xenogeneic MLR system. The xenoreactive murine T cells were restimulated by distinct human stimulator cells that had no shared HLA antigens with the stimulator used in the primary MLR. The data presented here show that the murine xenoreactive T cells recognize the shared determinant(s) of HLA-DR antigen on non-T, non-B stimulator cells. The xenoreactive murine T cell proliferative responses were mediated by Thy-1+, Lyt-1+, and Lyt-2- cells. Furthermore, the xenoreactive T cell responses required Ia+ cells, and Ia antigen on accessory cells plays a crucial role in eliciting the xenoreactive responses against human stimulator cells, while Ia+ accessory cells in the responding cell population are not essential for the elicitation of allogeneic MLR responses, as reported previously.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6202762

Citation

Yoshizawa, K, and A Yano. "Mouse T Lymphocytes Proliferative Responses Specific for Human MHC Products in Mouse Anti-human Xenogeneic MLR." Journal of Immunology (Baltimore, Md. : 1950), vol. 132, no. 6, 1984, pp. 2820-9.
Yoshizawa K, Yano A. Mouse T lymphocytes proliferative responses specific for human MHC products in mouse anti-human xenogeneic MLR. J Immunol. 1984;132(6):2820-9.
Yoshizawa, K., & Yano, A. (1984). Mouse T lymphocytes proliferative responses specific for human MHC products in mouse anti-human xenogeneic MLR. Journal of Immunology (Baltimore, Md. : 1950), 132(6), 2820-9.
Yoshizawa K, Yano A. Mouse T Lymphocytes Proliferative Responses Specific for Human MHC Products in Mouse Anti-human Xenogeneic MLR. J Immunol. 1984;132(6):2820-9. PubMed PMID: 6202762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mouse T lymphocytes proliferative responses specific for human MHC products in mouse anti-human xenogeneic MLR. AU - Yoshizawa,K, AU - Yano,A, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 2820 EP - 9 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 132 IS - 6 N2 - It has been reported that human T cells recognize the polymorphism of murine Ia antigens in the human anti-mouse xenogeneic mixed lymphocyte reactions (MLR). In this study, murine T cell recognition of human Class II antigens of the major histocompatibility complex (MHC) was analyzed in mouse anti-human xenogeneic MLR responses. The xenoreactive murine T cell proliferative response was blocked by adding anti-HLA-DR monoclonal antibody to the xenogeneic MLR culture. The specificity of xenoreactive murine T cells was examined with regard to the secondary and tertiary xenogeneic MLR system. The xenoreactive murine T cells were restimulated by distinct human stimulator cells that had no shared HLA antigens with the stimulator used in the primary MLR. The data presented here show that the murine xenoreactive T cells recognize the shared determinant(s) of HLA-DR antigen on non-T, non-B stimulator cells. The xenoreactive murine T cell proliferative responses were mediated by Thy-1+, Lyt-1+, and Lyt-2- cells. Furthermore, the xenoreactive T cell responses required Ia+ cells, and Ia antigen on accessory cells plays a crucial role in eliciting the xenoreactive responses against human stimulator cells, while Ia+ accessory cells in the responding cell population are not essential for the elicitation of allogeneic MLR responses, as reported previously. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6202762/Mouse_T_lymphocytes_proliferative_responses_specific_for_human_MHC_products_in_mouse_anti_human_xenogeneic_MLR_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6202762 DB - PRIME DP - Unbound Medicine ER -