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Mechanism of control of DNA replication and incompatibility in ColE1-type plasmids--a review.
Gene. 1984 Apr; 28(1):1-15.GENE

Abstract

The related phenomena of ColE1 DNA replication control and plasmid incompatibility are analysed in detail. Replication is negatively regulated in different ways by two gene products, RNA I and gene rop-coded polypeptide, while plasmid incompatibility is specified only by RNA I. Thus, copy-number mutants in the RNA I region usually have altered incompatibility and vice versa. RNA I is transcribed from the opposite strand to RNA II; the processed RNA II transcript serves as the primer for DNA replication. The base-pairing interaction between RNA I and RNA II controls DNA synthesis and incompatibility by preventing primer formation. A model is proposed to explain the phenotype of RNA I mutants in terms of the changes they cause in the secondary structure of RNA I or RNA II.

Authors

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Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6203811

Citation

Davison, J. "Mechanism of Control of DNA Replication and Incompatibility in ColE1-type Plasmids--a Review." Gene, vol. 28, no. 1, 1984, pp. 1-15.
Davison J. Mechanism of control of DNA replication and incompatibility in ColE1-type plasmids--a review. Gene. 1984;28(1):1-15.
Davison, J. (1984). Mechanism of control of DNA replication and incompatibility in ColE1-type plasmids--a review. Gene, 28(1), 1-15.
Davison J. Mechanism of Control of DNA Replication and Incompatibility in ColE1-type Plasmids--a Review. Gene. 1984;28(1):1-15. PubMed PMID: 6203811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of control of DNA replication and incompatibility in ColE1-type plasmids--a review. A1 - Davison,J, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 1 EP - 15 JF - Gene JO - Gene VL - 28 IS - 1 N2 - The related phenomena of ColE1 DNA replication control and plasmid incompatibility are analysed in detail. Replication is negatively regulated in different ways by two gene products, RNA I and gene rop-coded polypeptide, while plasmid incompatibility is specified only by RNA I. Thus, copy-number mutants in the RNA I region usually have altered incompatibility and vice versa. RNA I is transcribed from the opposite strand to RNA II; the processed RNA II transcript serves as the primer for DNA replication. The base-pairing interaction between RNA I and RNA II controls DNA synthesis and incompatibility by preventing primer formation. A model is proposed to explain the phenotype of RNA I mutants in terms of the changes they cause in the secondary structure of RNA I or RNA II. SN - 0378-1119 UR - https://www.unboundmedicine.com/medline/citation/6203811/Mechanism_of_control_of_DNA_replication_and_incompatibility_in_ColE1_type_plasmids__a_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-1119(84)90082-9 DB - PRIME DP - Unbound Medicine ER -