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Role of myelin antigens in murine relapsing experimental allergic encephalomyelitis.
J Clin Lab Immunol. 1984 Apr; 13(4):179-82.JC

Abstract

Delayed, relapsing experimental allergic encephalomyelitis (DR-EAE) has been shown to be a good model of multiple sclerosis. This disorder has been produced in mice by immunization with whole central nervous system (CNS) tissue and adjuvants. The ability of various myelin components to produce DR-EAE was studied. Guinea pig myelin basic protein was able to induce DR-EAE that was clinically and pathologically identical to disease produced by whole CNS. Both acute inflammatory and chronic demyelinating lesions were seen in the CNS. Allogeneic mouse myelin basic protein either alone or in combination with cerebrosides and/or gangliosides was not able to produce DR-EAE.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6204053

Citation

Lublin, F D.. "Role of Myelin Antigens in Murine Relapsing Experimental Allergic Encephalomyelitis." Journal of Clinical & Laboratory Immunology, vol. 13, no. 4, 1984, pp. 179-82.
Lublin FD. Role of myelin antigens in murine relapsing experimental allergic encephalomyelitis. J Clin Lab Immunol. 1984;13(4):179-82.
Lublin, F. D. (1984). Role of myelin antigens in murine relapsing experimental allergic encephalomyelitis. Journal of Clinical & Laboratory Immunology, 13(4), 179-82.
Lublin FD. Role of Myelin Antigens in Murine Relapsing Experimental Allergic Encephalomyelitis. J Clin Lab Immunol. 1984;13(4):179-82. PubMed PMID: 6204053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of myelin antigens in murine relapsing experimental allergic encephalomyelitis. A1 - Lublin,F D, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 179 EP - 82 JF - Journal of clinical & laboratory immunology JO - J Clin Lab Immunol VL - 13 IS - 4 N2 - Delayed, relapsing experimental allergic encephalomyelitis (DR-EAE) has been shown to be a good model of multiple sclerosis. This disorder has been produced in mice by immunization with whole central nervous system (CNS) tissue and adjuvants. The ability of various myelin components to produce DR-EAE was studied. Guinea pig myelin basic protein was able to induce DR-EAE that was clinically and pathologically identical to disease produced by whole CNS. Both acute inflammatory and chronic demyelinating lesions were seen in the CNS. Allogeneic mouse myelin basic protein either alone or in combination with cerebrosides and/or gangliosides was not able to produce DR-EAE. SN - 0141-2760 UR - https://www.unboundmedicine.com/medline/citation/6204053/Role_of_myelin_antigens_in_murine_relapsing_experimental_allergic_encephalomyelitis_ DB - PRIME DP - Unbound Medicine ER -