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The effect of tartrazine on histamine release from rat peritoneal mast cells.
Int J Immunopharmacol. 1984; 6(3):233-40.IJ

Abstract

The release of histamine from purified rat peritoneal mast cells induced by specific antigen (egg albumin), compound 48/80 and calcium ionophore A23187 was modified by tartrazine. Histamine release induced by 48/80 and antigen was inhibited by the presence of 10(-5) to 10(-2)M tartrazine. The inhibitory effect on egg albumin induced histamine release was maximal when the tartrazine was added simultaneously with egg albumin, and was reduced by increased preincubation of the cells with tartrazine. Tartrazine had a small inhibitory effect on ionophore induced release at high concentrations, but augmented histamine release at tartrazine concentrations of 10(-3) and 10(-4)M. Augmentation of ionophore induced release was maximal at between 0-5 min preincubation of the cells with tartrazine.

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Publisher Full Text

Authors

Safford RJ
No affiliation info available
Goodwin BF
No affiliation info available

MeSH

AnimalsAscitic FluidAzo CompoundsCalcimycinDrug InteractionsHistamine ReleaseIn Vitro TechniquesMaleMast CellsRatsRats, Inbred StrainsTartrazineTime Factorsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6204951

Citation

Safford, R J., and B F. Goodwin. "The Effect of Tartrazine On Histamine Release From Rat Peritoneal Mast Cells." International Journal of Immunopharmacology, vol. 6, no. 3, 1984, pp. 233-40.
Safford RJ, Goodwin BF. The effect of tartrazine on histamine release from rat peritoneal mast cells. Int J Immunopharmacol. 1984;6(3):233-40.
Safford, R. J., & Goodwin, B. F. (1984). The effect of tartrazine on histamine release from rat peritoneal mast cells. International Journal of Immunopharmacology, 6(3), 233-40.
Safford RJ, Goodwin BF. The Effect of Tartrazine On Histamine Release From Rat Peritoneal Mast Cells. Int J Immunopharmacol. 1984;6(3):233-40. PubMed PMID: 6204951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of tartrazine on histamine release from rat peritoneal mast cells. AU - Safford,R J, AU - Goodwin,B F, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 233 EP - 40 JF - International journal of immunopharmacology JO - Int J Immunopharmacol VL - 6 IS - 3 N2 - The release of histamine from purified rat peritoneal mast cells induced by specific antigen (egg albumin), compound 48/80 and calcium ionophore A23187 was modified by tartrazine. Histamine release induced by 48/80 and antigen was inhibited by the presence of 10(-5) to 10(-2)M tartrazine. The inhibitory effect on egg albumin induced histamine release was maximal when the tartrazine was added simultaneously with egg albumin, and was reduced by increased preincubation of the cells with tartrazine. Tartrazine had a small inhibitory effect on ionophore induced release at high concentrations, but augmented histamine release at tartrazine concentrations of 10(-3) and 10(-4)M. Augmentation of ionophore induced release was maximal at between 0-5 min preincubation of the cells with tartrazine. SN - 0192-0561 UR - https://www.unboundmedicine.com/medline/citation/6204951/The_effect_of_tartrazine_on_histamine_release_from_rat_peritoneal_mast_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0192-0561(84)90021-3 DB - PRIME DP - Unbound Medicine ER -