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HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB.
Tissue Antigens. 1984 May; 23(5):290-300.TA

Abstract

We describe three human proliferating T cell colonies, derived from mixed leukocyte culture with a non-diabetic individual (DR3 + 4) as the source of responding cells and an insulin-dependent diabetic patient (also DR3 + 4) as the source of stimulating cells. One colony detects HLA-Dw10 or a closely related antigen, and two detect an antigen that we call BO1 (Boston 1). BO1 is found so far on cells of all persons with DR5, about half of those with DRw6, and a particular subset of those with DR3. Among DR3-positive subjects, BO1 is positively correlated with HLA-B18 and BfF1, and negatively correlated with HLA-B8. These findings suggest that BO1 occurs in linkage disequilibrium with DR5, DRw6, and the haplotype B18, BfF1, DR3, the latter being common in southern Europe and reported previously to be a marker for insulin-dependent diabetes. In limited testing (21 subjects), BO1 was completely included in the supertypic specificity MT2, BO1 is a Class II HLA antigen, as demonstrated by blocking with monoclonal antibodies, but is distinct from all known antigens of the DR, MB(DC), MT, and SB series. It could be located on the same polypeptide chain as one or more of these antigen groups, however, particularly DR and/or MT.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6205468

Citation

Sheehy, M J., et al. "HLA Antigens of Insulin-dependent Diabetics. I. PLT Colonies Detecting Dw10 and a New Class II Determinant Distinct From HLA-D, DR, MB(DC), MT, and SB." Tissue Antigens, vol. 23, no. 5, 1984, pp. 290-300.
Sheehy MJ, Quintieri FB, Yang SY, et al. HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB. Tissue Antigens. 1984;23(5):290-300.
Sheehy, M. J., Quintieri, F. B., Yang, S. Y., Alosco, S. M., Matsui, Y., Yunis, E. J., & Gabbay, K. H. (1984). HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB. Tissue Antigens, 23(5), 290-300.
Sheehy MJ, et al. HLA Antigens of Insulin-dependent Diabetics. I. PLT Colonies Detecting Dw10 and a New Class II Determinant Distinct From HLA-D, DR, MB(DC), MT, and SB. Tissue Antigens. 1984;23(5):290-300. PubMed PMID: 6205468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB. AU - Sheehy,M J, AU - Quintieri,F B, AU - Yang,S Y, AU - Alosco,S M, AU - Matsui,Y, AU - Yunis,E J, AU - Gabbay,K H, PY - 1984/5/1/pubmed PY - 1984/5/1/medline PY - 1984/5/1/entrez SP - 290 EP - 300 JF - Tissue antigens JO - Tissue Antigens VL - 23 IS - 5 N2 - We describe three human proliferating T cell colonies, derived from mixed leukocyte culture with a non-diabetic individual (DR3 + 4) as the source of responding cells and an insulin-dependent diabetic patient (also DR3 + 4) as the source of stimulating cells. One colony detects HLA-Dw10 or a closely related antigen, and two detect an antigen that we call BO1 (Boston 1). BO1 is found so far on cells of all persons with DR5, about half of those with DRw6, and a particular subset of those with DR3. Among DR3-positive subjects, BO1 is positively correlated with HLA-B18 and BfF1, and negatively correlated with HLA-B8. These findings suggest that BO1 occurs in linkage disequilibrium with DR5, DRw6, and the haplotype B18, BfF1, DR3, the latter being common in southern Europe and reported previously to be a marker for insulin-dependent diabetes. In limited testing (21 subjects), BO1 was completely included in the supertypic specificity MT2, BO1 is a Class II HLA antigen, as demonstrated by blocking with monoclonal antibodies, but is distinct from all known antigens of the DR, MB(DC), MT, and SB series. It could be located on the same polypeptide chain as one or more of these antigen groups, however, particularly DR and/or MT. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/6205468/HLA_antigens_of_insulin_dependent_diabetics__I__PLT_colonies_detecting_Dw10_and_a_new_class_II_determinant_distinct_from_HLA_D_DR_MB_DC__MT_and_SB_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=1984&volume=23&issue=5&spage=290 DB - PRIME DP - Unbound Medicine ER -