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Oral tocainide versus disopyramide: a double-blind, randomized, crossover study of outpatients with stable ventricular premature beats.
J Cardiovasc Pharmacol. 1984 Jul-Aug; 6(4):657-62.JC

Abstract

Oral tocainide and disopyramide were compared in a double-blind, crossover trial in 10 outpatients with stable ventricular premature beats (VPBs). Efficacy was assessed by suppression of VPB activity and reduction of VPB grade during an exercise test and an 18-h Holter recording. An estimate of variance of VPB activity was obtained from two separate placebo periods, and a 95% confidence limit for VPB suppression was calculated. During Holter recording, both drugs produced a significant reduction in VPB frequency and grade (p less than 0.05). During the exercise challenge, tocainide produced a reduction in VPB frequency and grade, but this did not reach statistical significance; VPB frequency was unaltered by disopyramide, but VPB grade was significantly reduced (p less than 0.01).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6206321

Citation

McLaran, C J., et al. "Oral Tocainide Versus Disopyramide: a Double-blind, Randomized, Crossover Study of Outpatients With Stable Ventricular Premature Beats." Journal of Cardiovascular Pharmacology, vol. 6, no. 4, 1984, pp. 657-62.
McLaran CJ, Hossack KF, Neilson GH, et al. Oral tocainide versus disopyramide: a double-blind, randomized, crossover study of outpatients with stable ventricular premature beats. J Cardiovasc Pharmacol. 1984;6(4):657-62.
McLaran, C. J., Hossack, K. F., Neilson, G. H., & Siskind, V. (1984). Oral tocainide versus disopyramide: a double-blind, randomized, crossover study of outpatients with stable ventricular premature beats. Journal of Cardiovascular Pharmacology, 6(4), 657-62.
McLaran CJ, et al. Oral Tocainide Versus Disopyramide: a Double-blind, Randomized, Crossover Study of Outpatients With Stable Ventricular Premature Beats. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):657-62. PubMed PMID: 6206321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral tocainide versus disopyramide: a double-blind, randomized, crossover study of outpatients with stable ventricular premature beats. AU - McLaran,C J, AU - Hossack,K F, AU - Neilson,G H, AU - Siskind,V, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 657 EP - 62 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 6 IS - 4 N2 - Oral tocainide and disopyramide were compared in a double-blind, crossover trial in 10 outpatients with stable ventricular premature beats (VPBs). Efficacy was assessed by suppression of VPB activity and reduction of VPB grade during an exercise test and an 18-h Holter recording. An estimate of variance of VPB activity was obtained from two separate placebo periods, and a 95% confidence limit for VPB suppression was calculated. During Holter recording, both drugs produced a significant reduction in VPB frequency and grade (p less than 0.05). During the exercise challenge, tocainide produced a reduction in VPB frequency and grade, but this did not reach statistical significance; VPB frequency was unaltered by disopyramide, but VPB grade was significantly reduced (p less than 0.01). SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/6206321/Oral_tocainide_versus_disopyramide:_a_double_blind_randomized_crossover_study_of_outpatients_with_stable_ventricular_premature_beats_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6206321.ui DB - PRIME DP - Unbound Medicine ER -