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Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes.
Am Rev Respir Dis. 1984 Nov; 130(5):766-71.AR

Abstract

We examined the immunologic phenotype and function of bronchoalveolar lymphocytes isolated from 4 pigeon breeders who developed symptoms of hypersensitivity pneumonitis on exposure to pigeons, and 6 asymptomatic but equally exposed individuals. Similar numbers of bronchoalveolar lymphocytes were found in symptomatic breeders compared with the asymptomatic, and the percent of T11, T4, and T8 bearing cells as well as the T4/T8 ratios were similar in both groups. Despite these similarities, the groups had significantly different functional activity. Bronchoalveolar lymphocytes from symptomatic breeders demonstrated a marked (p less than 0.001) increase in blastogenic activity to both phytohemagglutinin and pigeon serum stimulation when compared with asymptomatic breeders. In addition, enriched bronchoalveolar T-cells suppressed the response of autologous preincubated peripheral blood lymphocytes to both phytohemagglutinin and pigeon serum in the asymptomatic compared with the symptomatic breeders. These studies suggest a discrepancy between the phenotype and function of immunoregulatory T-cell subsets in bronchoalveolar lavage lymphocytes in pigeon breeder's disease, and support a role for functional immunoregulatory imbalances in the pathogenesis of hypersensitivity pneumonitis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6208833

Citation

Keller, R H., et al. "Immunoregulation in Hypersensitivity Pneumonitis: Phenotypic and Functional Studies of Bronchoalveolar Lavage Lymphocytes." The American Review of Respiratory Disease, vol. 130, no. 5, 1984, pp. 766-71.
Keller RH, Swartz S, Schlueter DP, et al. Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes. Am Rev Respir Dis. 1984;130(5):766-71.
Keller, R. H., Swartz, S., Schlueter, D. P., Bar-Sela, S., & Fink, J. N. (1984). Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes. The American Review of Respiratory Disease, 130(5), 766-71.
Keller RH, et al. Immunoregulation in Hypersensitivity Pneumonitis: Phenotypic and Functional Studies of Bronchoalveolar Lavage Lymphocytes. Am Rev Respir Dis. 1984;130(5):766-71. PubMed PMID: 6208833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes. AU - Keller,R H, AU - Swartz,S, AU - Schlueter,D P, AU - Bar-Sela,S, AU - Fink,J N, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 766 EP - 71 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 130 IS - 5 N2 - We examined the immunologic phenotype and function of bronchoalveolar lymphocytes isolated from 4 pigeon breeders who developed symptoms of hypersensitivity pneumonitis on exposure to pigeons, and 6 asymptomatic but equally exposed individuals. Similar numbers of bronchoalveolar lymphocytes were found in symptomatic breeders compared with the asymptomatic, and the percent of T11, T4, and T8 bearing cells as well as the T4/T8 ratios were similar in both groups. Despite these similarities, the groups had significantly different functional activity. Bronchoalveolar lymphocytes from symptomatic breeders demonstrated a marked (p less than 0.001) increase in blastogenic activity to both phytohemagglutinin and pigeon serum stimulation when compared with asymptomatic breeders. In addition, enriched bronchoalveolar T-cells suppressed the response of autologous preincubated peripheral blood lymphocytes to both phytohemagglutinin and pigeon serum in the asymptomatic compared with the symptomatic breeders. These studies suggest a discrepancy between the phenotype and function of immunoregulatory T-cell subsets in bronchoalveolar lavage lymphocytes in pigeon breeder's disease, and support a role for functional immunoregulatory imbalances in the pathogenesis of hypersensitivity pneumonitis. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/6208833/Immunoregulation_in_hypersensitivity_pneumonitis:_phenotypic_and_functional_studies_of_bronchoalveolar_lavage_lymphocytes_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1984.130.5.766?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -