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Acne: endocrinologic aspects.
Cutis. 1982 Aug; 30(2):212-4, 216-7, 219 passim.C

Abstract

Acne is dependent for its development on several factors, one of which is hormonal. The principal and possibly sole mechanistic link between hormones and acne is sebum, the secretory product of the sebaceous glands which is highly androgen-sensitive. Some but not all, patients with acne can be shown to have systemic androgen abnormalities. In addition, there is evidence to suggest that androgens are metabolized abnormally in the skin, possibly resulting in excessive sebaceous gland secretion. Systemic endocrine therapy of acne is designed to reduce the androgenic stimulation of the sebaceous gland. Such treatment includes the peroral cyclic administration of estrogen for ovarian inhibition and the use of low-dosage glucocorticoid for adrenocortical androgen suppression. Combined estrogen-glucocorticoid treatment induces the most telling effect in reducing sebaceous gland activity.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6215213

Citation

Pochi, P E.. "Acne: Endocrinologic Aspects." Cutis, vol. 30, no. 2, 1982, 212-4, 216-7, 219 passim.
Pochi PE. Acne: endocrinologic aspects. Cutis. 1982;30(2):212-4, 216-7, 219 passim.
Pochi, P. E. (1982). Acne: endocrinologic aspects. Cutis, 30(2), 212-4, 216-7, 219 passim.
Pochi PE. Acne: Endocrinologic Aspects. Cutis. 1982;30(2):212-4, 216-7, 219 passim. PubMed PMID: 6215213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acne: endocrinologic aspects. A1 - Pochi,P E, PY - 1982/8/1/pubmed PY - 1982/8/1/medline PY - 1982/8/1/entrez SP - 212-4, 216-7, 219 passim JF - Cutis JO - Cutis VL - 30 IS - 2 N2 - Acne is dependent for its development on several factors, one of which is hormonal. The principal and possibly sole mechanistic link between hormones and acne is sebum, the secretory product of the sebaceous glands which is highly androgen-sensitive. Some but not all, patients with acne can be shown to have systemic androgen abnormalities. In addition, there is evidence to suggest that androgens are metabolized abnormally in the skin, possibly resulting in excessive sebaceous gland secretion. Systemic endocrine therapy of acne is designed to reduce the androgenic stimulation of the sebaceous gland. Such treatment includes the peroral cyclic administration of estrogen for ovarian inhibition and the use of low-dosage glucocorticoid for adrenocortical androgen suppression. Combined estrogen-glucocorticoid treatment induces the most telling effect in reducing sebaceous gland activity. SN - 0011-4162 UR - https://www.unboundmedicine.com/medline/citation/6215213/Acne:_endocrinologic_aspects_ L2 - https://medlineplus.gov/acne.html DB - PRIME DP - Unbound Medicine ER -