Tags

Type your tag names separated by a space and hit enter

The origin of androgen synthesis in polycystic ovary syndrome.
Obstet Gynecol. 1983 Nov; 62(5):601-4.OG

Abstract

The site of androgen synthesis was determined in 21 women with polycystic ovary syndrome on the basis of radiographic studies, catheterization of ovarian and adrenal veins, and/or inferior vena cava samplings. Gradients of testosterone, androstenedione, and dehydroepiandrosterone sulfate were determined by comparing the levels in adrenal and ovarian veins with those found in antecubital veins. In six patients, the adrenals were the predominant site of androgen synthesis. In five patients, both the ovaries and adrenals participated equally in androgen production. A good correlation was observed between the results obtained from gonadal and adrenal vein catheterizations and dynamic studies using stimulation with pregnyl and inhibition with dexamethasone. The results point to the important role of adrenals and ovaries in androgen overproduction. Stimulation and inhibition tests were in agreement with catheterization data. No correlation was found between morphology and hormonal disturbances.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6225965

Citation

Milewicz, A, et al. "The Origin of Androgen Synthesis in Polycystic Ovary Syndrome." Obstetrics and Gynecology, vol. 62, no. 5, 1983, pp. 601-4.
Milewicz A, Silber D, Mielecki T. The origin of androgen synthesis in polycystic ovary syndrome. Obstet Gynecol. 1983;62(5):601-4.
Milewicz, A., Silber, D., & Mielecki, T. (1983). The origin of androgen synthesis in polycystic ovary syndrome. Obstetrics and Gynecology, 62(5), 601-4.
Milewicz A, Silber D, Mielecki T. The Origin of Androgen Synthesis in Polycystic Ovary Syndrome. Obstet Gynecol. 1983;62(5):601-4. PubMed PMID: 6225965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The origin of androgen synthesis in polycystic ovary syndrome. AU - Milewicz,A, AU - Silber,D, AU - Mielecki,T, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 601 EP - 4 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 62 IS - 5 N2 - The site of androgen synthesis was determined in 21 women with polycystic ovary syndrome on the basis of radiographic studies, catheterization of ovarian and adrenal veins, and/or inferior vena cava samplings. Gradients of testosterone, androstenedione, and dehydroepiandrosterone sulfate were determined by comparing the levels in adrenal and ovarian veins with those found in antecubital veins. In six patients, the adrenals were the predominant site of androgen synthesis. In five patients, both the ovaries and adrenals participated equally in androgen production. A good correlation was observed between the results obtained from gonadal and adrenal vein catheterizations and dynamic studies using stimulation with pregnyl and inhibition with dexamethasone. The results point to the important role of adrenals and ovaries in androgen overproduction. Stimulation and inhibition tests were in agreement with catheterization data. No correlation was found between morphology and hormonal disturbances. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/6225965/The_origin_of_androgen_synthesis_in_polycystic_ovary_syndrome_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6225965.ui DB - PRIME DP - Unbound Medicine ER -