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Keratoderma and spastic paralysis.
Br J Dermatol. 1983 Nov; 109(5):589-96.BJ

Abstract

Punctate keratoderma and spastic paralysis occurred in three generations of a family. Several members had keratoderma of the palms and soles or spastic paralysis or both. The family history was consistent with autosomal-dominant inheritance. The age at onset and the rate of progression of symptoms were variable. The concurrence of these lesions can be interpreted to mean either that the keratoderma and the paraplegia are the pleiotropic effects of the same mutant gene or, less likely, that they are the manifestations of two different autosomal mutations segregating in this family. We are not aware of a similar syndrome having been previously reported.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6227331

Citation

Powell, F C., et al. "Keratoderma and Spastic Paralysis." The British Journal of Dermatology, vol. 109, no. 5, 1983, pp. 589-96.
Powell FC, Venencie PY, Gordon H, et al. Keratoderma and spastic paralysis. Br J Dermatol. 1983;109(5):589-96.
Powell, F. C., Venencie, P. Y., Gordon, H., & Winkelmann, R. K. (1983). Keratoderma and spastic paralysis. The British Journal of Dermatology, 109(5), 589-96.
Powell FC, et al. Keratoderma and Spastic Paralysis. Br J Dermatol. 1983;109(5):589-96. PubMed PMID: 6227331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Keratoderma and spastic paralysis. AU - Powell,F C, AU - Venencie,P Y, AU - Gordon,H, AU - Winkelmann,R K, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 589 EP - 96 JF - The British journal of dermatology JO - Br J Dermatol VL - 109 IS - 5 N2 - Punctate keratoderma and spastic paralysis occurred in three generations of a family. Several members had keratoderma of the palms and soles or spastic paralysis or both. The family history was consistent with autosomal-dominant inheritance. The age at onset and the rate of progression of symptoms were variable. The concurrence of these lesions can be interpreted to mean either that the keratoderma and the paraplegia are the pleiotropic effects of the same mutant gene or, less likely, that they are the manifestations of two different autosomal mutations segregating in this family. We are not aware of a similar syndrome having been previously reported. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/6227331/Keratoderma_and_spastic_paralysis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1983&volume=109&issue=5&spage=589 DB - PRIME DP - Unbound Medicine ER -