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A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man.
J Clin Invest. 1984 Jan; 73(1):262-6.JCI

Abstract

The effect of the luteinizing hormone-releasing hormone (LHRH) agonist, [D-Trp6,Pro9-NEth]LHRH (LHRHA), on luteinizing hormone (LH) bioactivity was assessed with a rat interstitial cell assay in four men during a 14-d treatment period. Biologic/immunologic (B/I) ratios were unchanged initially with treatment but by day 12 had fallen to levels lower than basal values. Frequent sampling on day 12 revealed blunted gonadotropin responsiveness to LHRHA and absence of spontaneous LH pulsations. Despite continued administration of LHRHA, human chorionic gonadotropin administration resulted in elevated B/I ratios and testosterone levels. Further characterization of the serum immunoreactive LH by Sephadex chromatography revealed a later elution profile during treatment with LHRHA. Thus, LHRHA appears to act, in part, by modification of the bioactivity of LH in man.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6228566

Citation

Evans, R M., et al. "A Luteinizing Hormone-releasing Hormone Agonist Decreases Biological Activity and Modifies Chromatographic Behavior of Luteinizing Hormone in Man." The Journal of Clinical Investigation, vol. 73, no. 1, 1984, pp. 262-6.
Evans RM, Doelle GC, Lindner J, et al. A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man. J Clin Invest. 1984;73(1):262-6.
Evans, R. M., Doelle, G. C., Lindner, J., Bradley, V., & Rabin, D. (1984). A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man. The Journal of Clinical Investigation, 73(1), 262-6.
Evans RM, et al. A Luteinizing Hormone-releasing Hormone Agonist Decreases Biological Activity and Modifies Chromatographic Behavior of Luteinizing Hormone in Man. J Clin Invest. 1984;73(1):262-6. PubMed PMID: 6228566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man. AU - Evans,R M, AU - Doelle,G C, AU - Lindner,J, AU - Bradley,V, AU - Rabin,D, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 262 EP - 6 JF - The Journal of clinical investigation JO - J Clin Invest VL - 73 IS - 1 N2 - The effect of the luteinizing hormone-releasing hormone (LHRH) agonist, [D-Trp6,Pro9-NEth]LHRH (LHRHA), on luteinizing hormone (LH) bioactivity was assessed with a rat interstitial cell assay in four men during a 14-d treatment period. Biologic/immunologic (B/I) ratios were unchanged initially with treatment but by day 12 had fallen to levels lower than basal values. Frequent sampling on day 12 revealed blunted gonadotropin responsiveness to LHRHA and absence of spontaneous LH pulsations. Despite continued administration of LHRHA, human chorionic gonadotropin administration resulted in elevated B/I ratios and testosterone levels. Further characterization of the serum immunoreactive LH by Sephadex chromatography revealed a later elution profile during treatment with LHRHA. Thus, LHRHA appears to act, in part, by modification of the bioactivity of LH in man. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/6228566/A_luteinizing_hormone_releasing_hormone_agonist_decreases_biological_activity_and_modifies_chromatographic_behavior_of_luteinizing_hormone_in_man_ L2 - https://doi.org/10.1172/JCI111200 DB - PRIME DP - Unbound Medicine ER -