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Lung T cells in hypersensitivity pneumonitis.
Ann Intern Med. 1984 Mar; 100(3):390-2.AIM

Abstract

Monoclonal antibodies OKT3 (all T cells), OKT4 (T-helper/inducer), and OKT8 (T-suppressor/cytotoxic) were used to determine surface phenotypes of bronchoalveolar lavage and peripheral blood lymphocytes in patients with chronic hypersensitivity pneumonitis. Similar studies were done in asymptomatic pigeon breeders, patients with sarcoidosis, and nonsmoking controls. Increased numbers of lavage T cells were found in patients with hypersensitivity pneumonitis and sarcoidosis and in asymptomatic pigeon breeders. The predominant T-cell subset in patients with hypersensitivity pneumonitis and in asymptomatic pigeon breeders was T8 +; in contrast, the predominant subset in those with sarcoidosis was T4 +. Peripheral blood T-cell subsets were normal in all groups. Thus, most lung T lymphocytes in chronic hypersensitivity pneumonitis belong to the T8 + subset; the local cellular immune response in hypersensitivity pneumonitis and sarcoidosis are different; and the pattern of alveolitis, as determined by bronchoalveolar lavage, is not the sole determinant of lung impairment after exposure to hypersensitivity pneumonitis antigens.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6230036

Citation

Leatherman, J W., et al. "Lung T Cells in Hypersensitivity Pneumonitis." Annals of Internal Medicine, vol. 100, no. 3, 1984, pp. 390-2.
Leatherman JW, Michael AF, Schwartz BA, et al. Lung T cells in hypersensitivity pneumonitis. Ann Intern Med. 1984;100(3):390-2.
Leatherman, J. W., Michael, A. F., Schwartz, B. A., & Hoidal, J. R. (1984). Lung T cells in hypersensitivity pneumonitis. Annals of Internal Medicine, 100(3), 390-2.
Leatherman JW, et al. Lung T Cells in Hypersensitivity Pneumonitis. Ann Intern Med. 1984;100(3):390-2. PubMed PMID: 6230036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung T cells in hypersensitivity pneumonitis. AU - Leatherman,J W, AU - Michael,A F, AU - Schwartz,B A, AU - Hoidal,J R, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 390 EP - 2 JF - Annals of internal medicine JO - Ann Intern Med VL - 100 IS - 3 N2 - Monoclonal antibodies OKT3 (all T cells), OKT4 (T-helper/inducer), and OKT8 (T-suppressor/cytotoxic) were used to determine surface phenotypes of bronchoalveolar lavage and peripheral blood lymphocytes in patients with chronic hypersensitivity pneumonitis. Similar studies were done in asymptomatic pigeon breeders, patients with sarcoidosis, and nonsmoking controls. Increased numbers of lavage T cells were found in patients with hypersensitivity pneumonitis and sarcoidosis and in asymptomatic pigeon breeders. The predominant T-cell subset in patients with hypersensitivity pneumonitis and in asymptomatic pigeon breeders was T8 +; in contrast, the predominant subset in those with sarcoidosis was T4 +. Peripheral blood T-cell subsets were normal in all groups. Thus, most lung T lymphocytes in chronic hypersensitivity pneumonitis belong to the T8 + subset; the local cellular immune response in hypersensitivity pneumonitis and sarcoidosis are different; and the pattern of alveolitis, as determined by bronchoalveolar lavage, is not the sole determinant of lung impairment after exposure to hypersensitivity pneumonitis antigens. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/6230036/Lung_T_cells_in_hypersensitivity_pneumonitis_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-100-3-390?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -