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Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat.
Cancer Res. 1984 Jul; 44(7):3007-11.CR

Abstract

An animal model is described to test the effect of diphosphonates, which are powerful antiosteolytic agents, against bone tumors. This model consists of injecting Walker tumor cells into one iliac artery of a series of rats while the contralateral artery is clamped during the injection, and waiting 7 days to obtain a significant destruction of the femur and tibia of the rats. In most of the animals, after this delay, extensive lesions are observed macroscopically by X-ray and histologically. The parenteral administration of three diphosphonates, dichloromethylene diphosphonate, ethanehydroxydiphosphonate , and aminopropanediphosphonate , at 16 and 160 mumol/kg/day, protects the bones by decreasing the extent of osteolysis. This protective effect is seen both in the tumor-injected leg and in the contralateral leg and is significant when compared to nontreated animals. The most active of the drugs was dichloromethylene-diphosphonate; ethanehydroxydiphosphonate and aminopropanediphosphonate were less active, especially when given at the higher dosage. All diphosphonates produce a marked decrease of the number of osteoclasts; ethanehydroxydiphosphonate at the higher dosage, induced a large increase of nonmineralized bone. These results are discussed in light of recent clinical work, showing that this animal model is a useful tool to test the effect of new drugs against osteolysis of cancer.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6233002

Citation

Jung, A, et al. "Inhibition By Diphosphonates of Bone Resorption Induced By the Walker Tumor of the Rat." Cancer Research, vol. 44, no. 7, 1984, pp. 3007-11.
Jung A, Bornand J, Mermillod B, et al. Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Cancer Res. 1984;44(7):3007-11.
Jung, A., Bornand, J., Mermillod, B., Edouard, C., & Meunier, P. J. (1984). Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Cancer Research, 44(7), 3007-11.
Jung A, et al. Inhibition By Diphosphonates of Bone Resorption Induced By the Walker Tumor of the Rat. Cancer Res. 1984;44(7):3007-11. PubMed PMID: 6233002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. AU - Jung,A, AU - Bornand,J, AU - Mermillod,B, AU - Edouard,C, AU - Meunier,P J, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 3007 EP - 11 JF - Cancer research JO - Cancer Res VL - 44 IS - 7 N2 - An animal model is described to test the effect of diphosphonates, which are powerful antiosteolytic agents, against bone tumors. This model consists of injecting Walker tumor cells into one iliac artery of a series of rats while the contralateral artery is clamped during the injection, and waiting 7 days to obtain a significant destruction of the femur and tibia of the rats. In most of the animals, after this delay, extensive lesions are observed macroscopically by X-ray and histologically. The parenteral administration of three diphosphonates, dichloromethylene diphosphonate, ethanehydroxydiphosphonate , and aminopropanediphosphonate , at 16 and 160 mumol/kg/day, protects the bones by decreasing the extent of osteolysis. This protective effect is seen both in the tumor-injected leg and in the contralateral leg and is significant when compared to nontreated animals. The most active of the drugs was dichloromethylene-diphosphonate; ethanehydroxydiphosphonate and aminopropanediphosphonate were less active, especially when given at the higher dosage. All diphosphonates produce a marked decrease of the number of osteoclasts; ethanehydroxydiphosphonate at the higher dosage, induced a large increase of nonmineralized bone. These results are discussed in light of recent clinical work, showing that this animal model is a useful tool to test the effect of new drugs against osteolysis of cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/6233002/Inhibition_by_diphosphonates_of_bone_resorption_induced_by_the_Walker_tumor_of_the_rat_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=6233002 DB - PRIME DP - Unbound Medicine ER -