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Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives.
Fertil Steril. 1984 Jun; 41(6):888-93.FS

Abstract

The hormonal profiles and the effect of oral contraceptives (OCs) on 16 oligomenorrheic and 10 regularly menstruating adolescent girls were studied. Testosterone, androstenedione, dehydroepiandrosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex-hormone-binding globulin were determined on blood samples obtained during a control cycle, during OC treatment, and during the follow-up cycle after discontinuation of OC use. The oligomenorrheic girls had significantly higher concentrations of androstenedione and total and free testosterone than regularly menstruating girls during the control cycle. Sex-hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. Both in oligomenorrheic and regularly menstruating girls OC treatment caused a decrease in the mean concentrations of all hormones, except prolactin, to similar levels. For 2 to 4 weeks after treatment the oligomenorrheic girls had significantly lower levels of androstenedione, total and free testosterone, and luteinizing hormone than before treatment. In the control group there were no significant differences between pretreatment and posttreatment hormone concentrations. The risks and benefits of prescribing OCs for oligomenorrheic adolescent girls are discussed.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6233177

Citation

Siegberg, R, et al. "Sex Hormone Profiles in Oligomenorrheic Adolescent Girls and the Effect of Oral Contraceptives." Fertility and Sterility, vol. 41, no. 6, 1984, pp. 888-93.
Siegberg R, Nilsson CG, Stenman UH, et al. Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives. Fertil Steril. 1984;41(6):888-93.
Siegberg, R., Nilsson, C. G., Stenman, U. H., & Widholm, O. (1984). Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives. Fertility and Sterility, 41(6), 888-93.
Siegberg R, et al. Sex Hormone Profiles in Oligomenorrheic Adolescent Girls and the Effect of Oral Contraceptives. Fertil Steril. 1984;41(6):888-93. PubMed PMID: 6233177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives. AU - Siegberg,R, AU - Nilsson,C G, AU - Stenman,U H, AU - Widholm,O, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez KW - Adolescent Pregnancy KW - Adolescents KW - Adolescents, Female KW - Age Factors KW - Androgens KW - Anthropometry KW - Biology KW - Body Weight KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Dehydroepiandrosterone KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Endocrine System KW - Estradiol KW - Estrogens KW - Europe KW - Examinations And Diagnoses KW - Family Planning KW - Fertility KW - Finland KW - Follicle Stimulating Hormone KW - Genital Effects, Female KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Growth KW - Hormones--analysis KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Luteinizing Hormone KW - Menarche KW - Menstrual Cycle--changes KW - Menstruation KW - Menstruation Disorders KW - Northern Europe KW - Oral Contraceptives--side effects KW - Physiology KW - Population KW - Population Characteristics KW - Population Dynamics KW - Progesterone KW - Prolactin KW - Reproduction KW - Reproductive Behavior KW - Reversibility KW - Scandinavia KW - Testosterone KW - Urogenital Effects KW - Urogenital System KW - Youth SP - 888 EP - 93 JF - Fertility and sterility JO - Fertil Steril VL - 41 IS - 6 N2 - The hormonal profiles and the effect of oral contraceptives (OCs) on 16 oligomenorrheic and 10 regularly menstruating adolescent girls were studied. Testosterone, androstenedione, dehydroepiandrosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex-hormone-binding globulin were determined on blood samples obtained during a control cycle, during OC treatment, and during the follow-up cycle after discontinuation of OC use. The oligomenorrheic girls had significantly higher concentrations of androstenedione and total and free testosterone than regularly menstruating girls during the control cycle. Sex-hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. Both in oligomenorrheic and regularly menstruating girls OC treatment caused a decrease in the mean concentrations of all hormones, except prolactin, to similar levels. For 2 to 4 weeks after treatment the oligomenorrheic girls had significantly lower levels of androstenedione, total and free testosterone, and luteinizing hormone than before treatment. In the control group there were no significant differences between pretreatment and posttreatment hormone concentrations. The risks and benefits of prescribing OCs for oligomenorrheic adolescent girls are discussed. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/6233177/Sex_hormone_profiles_in_oligomenorrheic_adolescent_girls_and_the_effect_of_oral_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)47903-3 DB - PRIME DP - Unbound Medicine ER -