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Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy.
Am J Physiol. 1984 Jun; 246(6 Pt 2):H761-7.AJ

Abstract

Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6234810

Citation

Hickson, R C., et al. "Androgen and Glucocorticoid Mechanisms in Exercise-induced Cardiac Hypertrophy." The American Journal of Physiology, vol. 246, no. 6 Pt 2, 1984, pp. H761-7.
Hickson RC, Galassi TM, Kurowski TT, et al. Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. Am J Physiol. 1984;246(6 Pt 2):H761-7.
Hickson, R. C., Galassi, T. M., Kurowski, T. T., Daniels, D. G., & Chatterton, R. T. (1984). Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. The American Journal of Physiology, 246(6 Pt 2), H761-7.
Hickson RC, et al. Androgen and Glucocorticoid Mechanisms in Exercise-induced Cardiac Hypertrophy. Am J Physiol. 1984;246(6 Pt 2):H761-7. PubMed PMID: 6234810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. AU - Hickson,R C, AU - Galassi,T M, AU - Kurowski,T T, AU - Daniels,D G, AU - Chatterton,R T,Jr PY - 1984/6/11/pubmed PY - 1984/6/11/medline PY - 1984/6/11/entrez SP - H761 EP - 7 JF - The American journal of physiology JO - Am J Physiol VL - 246 IS - 6 Pt 2 N2 - Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/6234810/Androgen_and_glucocorticoid_mechanisms_in_exercise_induced_cardiac_hypertrophy_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.1984.246.6.H761?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -