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Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy.
Am J Physiol. 1984 Jun; 246(6 Pt 2):H761-7.AJ

Abstract

Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy.

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Publisher Full Text

Authors

Hickson RC
No affiliation info available
Galassi TM
No affiliation info available
Kurowski TT
No affiliation info available
Daniels DG
No affiliation info available
Chatterton RT
No affiliation info available

MeSH

AndrogensAnimalsCardiomegalyFemaleGlucocorticoidsHeart VentriclesOrgan SizePhysical ExertionRatsRats, Inbred StrainsReceptors, AndrogenReceptors, GlucocorticoidSwimmingTritium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6234810

Citation

Hickson, R C., et al. "Androgen and Glucocorticoid Mechanisms in Exercise-induced Cardiac Hypertrophy." The American Journal of Physiology, vol. 246, no. 6 Pt 2, 1984, pp. H761-7.
Hickson RC, Galassi TM, Kurowski TT, et al. Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. Am J Physiol. 1984;246(6 Pt 2):H761-7.
Hickson, R. C., Galassi, T. M., Kurowski, T. T., Daniels, D. G., & Chatterton, R. T. (1984). Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. The American Journal of Physiology, 246(6 Pt 2), H761-7.
Hickson RC, et al. Androgen and Glucocorticoid Mechanisms in Exercise-induced Cardiac Hypertrophy. Am J Physiol. 1984;246(6 Pt 2):H761-7. PubMed PMID: 6234810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. AU - Hickson,R C, AU - Galassi,T M, AU - Kurowski,T T, AU - Daniels,D G, AU - Chatterton,R T,Jr PY - 1984/6/11/pubmed PY - 1984/6/11/medline PY - 1984/6/11/entrez SP - H761 EP - 7 JF - The American journal of physiology JO - Am J Physiol VL - 246 IS - 6 Pt 2 N2 - Female rats were trained daily by means of two 2-h-long bouts of swimming separated by a 30- to 40-min rest period. Absolute ventricular weights of the swimmers were increased above sedentary control values by 6% after 2 days, 15% after 7 days, and 30% after 35 days of exercise. Resting levels of total and free serum testosterone and total 5 alpha-dihydrotestosterone were not altered by the training. Total serum corticosterone concentrations at rest were significantly lower in the 7-day (149 +/- 16 ng/ml) and 35-day (169 +/- 24) swimmers compared with the controls (293 +/- 26). However, free corticosterone was not significantly reduced from controls in any of the swimming groups. Ventricular muscle cytosol androgen receptor binding dissociation constants and receptor binding capacities, measured using [3H]methyltrienolone (R1881), were not significantly different from control values in the exercised groups. Glucocorticoid cytosol receptor binding capacity in ventricular tissue, determined using [3H]dexamethasone, was significantly increased as femtomoles per milligram protein (39.3 +/- 3.1 vs. 31.4 +/- 1.4) and femtomoles per milligram DNA (2,683 +/- 226 vs. 1,786 +/- 71). These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/6234810/Androgen_and_glucocorticoid_mechanisms_in_exercise_induced_cardiac_hypertrophy_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.1984.246.6.H761?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -