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Autoimmune effector cells. VI. Transfer of experimental allergic encephalomyelitis with spleen cells activated in mixed lymphocyte cultures.
J Immunol. 1984 Oct; 133(4):1943-5.JI

Abstract

Although spleen cells (SpC) from Lewis rats that have been immunized with guinea pig myelin basic protein in complete Freund's adjuvant do not transfer experimental autoimmune encephalomyelitis (EAE) to syngeneic recipients, we report that effector cells of EAE can be activated in SpC suspensions during mixed lymphocyte reactions (MLR) to allogeneic SpC. Effector cell activation correlates with interleukin 2 (IL 2) production. The results are consistent with the hypothesis that autoreactive cells may be generated as a result of an immune response to exogenous antigens.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6236261

Citation

Hayosh, N S., et al. "Autoimmune Effector Cells. VI. Transfer of Experimental Allergic Encephalomyelitis With Spleen Cells Activated in Mixed Lymphocyte Cultures." Journal of Immunology (Baltimore, Md. : 1950), vol. 133, no. 4, 1984, pp. 1943-5.
Hayosh NS, Simon LL, Swanborg RH. Autoimmune effector cells. VI. Transfer of experimental allergic encephalomyelitis with spleen cells activated in mixed lymphocyte cultures. J Immunol. 1984;133(4):1943-5.
Hayosh, N. S., Simon, L. L., & Swanborg, R. H. (1984). Autoimmune effector cells. VI. Transfer of experimental allergic encephalomyelitis with spleen cells activated in mixed lymphocyte cultures. Journal of Immunology (Baltimore, Md. : 1950), 133(4), 1943-5.
Hayosh NS, Simon LL, Swanborg RH. Autoimmune Effector Cells. VI. Transfer of Experimental Allergic Encephalomyelitis With Spleen Cells Activated in Mixed Lymphocyte Cultures. J Immunol. 1984;133(4):1943-5. PubMed PMID: 6236261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune effector cells. VI. Transfer of experimental allergic encephalomyelitis with spleen cells activated in mixed lymphocyte cultures. AU - Hayosh,N S, AU - Simon,L L, AU - Swanborg,R H, PY - 1984/10/1/pubmed PY - 1984/10/1/medline PY - 1984/10/1/entrez SP - 1943 EP - 5 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 133 IS - 4 N2 - Although spleen cells (SpC) from Lewis rats that have been immunized with guinea pig myelin basic protein in complete Freund's adjuvant do not transfer experimental autoimmune encephalomyelitis (EAE) to syngeneic recipients, we report that effector cells of EAE can be activated in SpC suspensions during mixed lymphocyte reactions (MLR) to allogeneic SpC. Effector cell activation correlates with interleukin 2 (IL 2) production. The results are consistent with the hypothesis that autoreactive cells may be generated as a result of an immune response to exogenous antigens. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6236261/Autoimmune_effector_cells__VI__Transfer_of_experimental_allergic_encephalomyelitis_with_spleen_cells_activated_in_mixed_lymphocyte_cultures_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6236261 DB - PRIME DP - Unbound Medicine ER -