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Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology.
Contraception. 1984 Jul; 30(1):73-9.C

Abstract

Eight healthy (apart from pelvic endometriosis) women were given daily doses of 0.125, 0.250 and 0.500 mg of desogestrel or 5 mg of lynestrenol orally in a randomized order. Duration of each treatment was 6 weeks. Serum was analyzed for sex hormone binding globulin (SHBG), ceruloplasmin, cortisol binding globulin (CBG), thyroxine binding globulin (TBG) and prealbumin using an electroimmunoassay. Serum 17 beta-estradiol (E2) and testosterone (T) were analyzed by radioimmunoassay. Vaginal cytology was studied using the maturation value (MV). E2 levels were depressed by desogestrel and lynestrenol apart from values in two women after 0.125 mg desogestrel. T concentration was suppressed by desogestrel but not by lynestrenol. SHBG concentration and MV were dose-dependently suppressed indicating an antiestrogenic or possibly androgenic effect of desogestrel and lynestrenol. No androgenic or anabolic effects of desogestrel were however seen, e.g. suppression of TBG content or increase in prealbumin levels. For lynestrenol, however, a small but significant increase in prealbumin concentration indicated a weak androgenic/anabolic effect. No estrogenic effects were seen, e.g. increases in ceruloplasmin, CBG levels or in elevations of MV. A depressed SHBG production ability in the hepatocytes during treatment with 19-nortestosterone derivatives is postulated, possibly due to competitive receptor binding.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6236952

Citation

Cullberg, G. "Androgenic, Anabolic, Estrogenic and Antiestrogenic Effects of Desogestrel and Lynestrenol: Effects On Serum Proteins and Vaginal Cytology." Contraception, vol. 30, no. 1, 1984, pp. 73-9.
Cullberg G. Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology. Contraception. 1984;30(1):73-9.
Cullberg, G. (1984). Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology. Contraception, 30(1), 73-9.
Cullberg G. Androgenic, Anabolic, Estrogenic and Antiestrogenic Effects of Desogestrel and Lynestrenol: Effects On Serum Proteins and Vaginal Cytology. Contraception. 1984;30(1):73-9. PubMed PMID: 6236952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology. A1 - Cullberg,G, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Diseases KW - Endocrine System KW - Endometrial Effects KW - Endometritis KW - Endometrium KW - Examinations And Diagnoses KW - Family Planning KW - Genital Effects, Female KW - Genitalia KW - Genitalia, Female KW - Hormones--administraction and dosage KW - Infections KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Lynestrenol--administraction and dosage KW - Physiology KW - Reproductive Control Agents KW - Reproductive Tract Infections KW - Research Methodology KW - Treatment KW - Urogenital Effects KW - Urogenital System KW - Uterine Effects KW - Uterus SP - 73 EP - 9 JF - Contraception JO - Contraception VL - 30 IS - 1 N2 - Eight healthy (apart from pelvic endometriosis) women were given daily doses of 0.125, 0.250 and 0.500 mg of desogestrel or 5 mg of lynestrenol orally in a randomized order. Duration of each treatment was 6 weeks. Serum was analyzed for sex hormone binding globulin (SHBG), ceruloplasmin, cortisol binding globulin (CBG), thyroxine binding globulin (TBG) and prealbumin using an electroimmunoassay. Serum 17 beta-estradiol (E2) and testosterone (T) were analyzed by radioimmunoassay. Vaginal cytology was studied using the maturation value (MV). E2 levels were depressed by desogestrel and lynestrenol apart from values in two women after 0.125 mg desogestrel. T concentration was suppressed by desogestrel but not by lynestrenol. SHBG concentration and MV were dose-dependently suppressed indicating an antiestrogenic or possibly androgenic effect of desogestrel and lynestrenol. No androgenic or anabolic effects of desogestrel were however seen, e.g. suppression of TBG content or increase in prealbumin levels. For lynestrenol, however, a small but significant increase in prealbumin concentration indicated a weak androgenic/anabolic effect. No estrogenic effects were seen, e.g. increases in ceruloplasmin, CBG levels or in elevations of MV. A depressed SHBG production ability in the hepatocytes during treatment with 19-nortestosterone derivatives is postulated, possibly due to competitive receptor binding. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/6236952/Androgenic_anabolic_estrogenic_and_antiestrogenic_effects_of_desogestrel_and_lynestrenol:_effects_on_serum_proteins_and_vaginal_cytology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(84)90080-5 DB - PRIME DP - Unbound Medicine ER -