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[Diphosphonates in the treatment of hypercalcemia].
Rev Med Interne. 1984 Nov; 5(4):363-6.RM

Abstract

The diphosphonates (DP) represent a new class of therapeutic agents, the main property of which is to block bone resorption, irrespective of its stimulus. Apart from their remarkable results in Paget's disease of the bone, DP are very effective in the treatment of hypercalcaemia the osseus origin of which is nearly always essential. In malignant hypercalcaemia, EHDP, C12 MDP and APD, the three DP tested in man, cause a fall in serum calcium in a few days when administered intravenously. The latter two preparations are also effective when given orally. DP are also valuable in controlling hypercalcaemia in primary hyperparathyroidism. Research is under way to determine the role of DP in the prevention of malignant osteolysis, as distinct from the effects of chemotherapy.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

fre

PubMed ID

6240753

Citation

Delmas, P D., and P J. Meunier. "[Diphosphonates in the Treatment of Hypercalcemia]." La Revue De Medecine Interne, vol. 5, no. 4, 1984, pp. 363-6.
Delmas PD, Meunier PJ. [Diphosphonates in the treatment of hypercalcemia]. Rev Med Interne. 1984;5(4):363-6.
Delmas, P. D., & Meunier, P. J. (1984). [Diphosphonates in the treatment of hypercalcemia]. La Revue De Medecine Interne, 5(4), 363-6.
Delmas PD, Meunier PJ. [Diphosphonates in the Treatment of Hypercalcemia]. Rev Med Interne. 1984;5(4):363-6. PubMed PMID: 6240753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diphosphonates in the treatment of hypercalcemia]. AU - Delmas,P D, AU - Meunier,P J, PY - 1984/11/1/pubmed PY - 1984/11/1/medline PY - 1984/11/1/entrez SP - 363 EP - 6 JF - La Revue de medecine interne JO - Rev Med Interne VL - 5 IS - 4 N2 - The diphosphonates (DP) represent a new class of therapeutic agents, the main property of which is to block bone resorption, irrespective of its stimulus. Apart from their remarkable results in Paget's disease of the bone, DP are very effective in the treatment of hypercalcaemia the osseus origin of which is nearly always essential. In malignant hypercalcaemia, EHDP, C12 MDP and APD, the three DP tested in man, cause a fall in serum calcium in a few days when administered intravenously. The latter two preparations are also effective when given orally. DP are also valuable in controlling hypercalcaemia in primary hyperparathyroidism. Research is under way to determine the role of DP in the prevention of malignant osteolysis, as distinct from the effects of chemotherapy. SN - 0248-8663 UR - https://www.unboundmedicine.com/medline/citation/6240753/[Diphosphonates_in_the_treatment_of_hypercalcemia]_ DB - PRIME DP - Unbound Medicine ER -
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