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[In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)].
C R Seances Soc Biol Fil. 1984; 178(4):458-66.CR

Abstract

delta 6- and delta 5-desaturations of linoleic [1(14)C] or dihomo-gamma-linolenic [2(14)C] acids are partially inhibited, in vitro, in liver microsomes of spontaneously hypertensive rats (SHR) comparatively to normotensive rats (WKY). The inhibition is more light when the animals are young and the blood hypertension not well established. These results are particularly important, for these desaturations are fundamental steps in the biosynthesis of prostaglandins precursors, prostaglandins and their original fatty acids being involved in blood pressure regulation.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

fre

PubMed ID

6241017

Citation

Narce, M, and J P. Poisson. "[In Vitro Study of Delta 6- and Delta 5-desaturations of Linoleic and Dihomo-gamma-linolenic Acids During the Development of Arterial Hypertension as a Function of Age in Spontaneously Hypertensive Rats (SHR) as Compared to Normotensive Rats (WKY)]." Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales, vol. 178, no. 4, 1984, pp. 458-66.
Narce M, Poisson JP. [In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)]. C R Seances Soc Biol Fil. 1984;178(4):458-66.
Narce, M., & Poisson, J. P. (1984). [In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)]. Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales, 178(4), 458-66.
Narce M, Poisson JP. [In Vitro Study of Delta 6- and Delta 5-desaturations of Linoleic and Dihomo-gamma-linolenic Acids During the Development of Arterial Hypertension as a Function of Age in Spontaneously Hypertensive Rats (SHR) as Compared to Normotensive Rats (WKY)]. C R Seances Soc Biol Fil. 1984;178(4):458-66. PubMed PMID: 6241017.
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TY - JOUR T1 - [In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)]. AU - Narce,M, AU - Poisson,J P, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 458 EP - 66 JF - Comptes rendus des seances de la Societe de biologie et de ses filiales JO - C R Seances Soc Biol Fil VL - 178 IS - 4 N2 - delta 6- and delta 5-desaturations of linoleic [1(14)C] or dihomo-gamma-linolenic [2(14)C] acids are partially inhibited, in vitro, in liver microsomes of spontaneously hypertensive rats (SHR) comparatively to normotensive rats (WKY). The inhibition is more light when the animals are young and the blood hypertension not well established. These results are particularly important, for these desaturations are fundamental steps in the biosynthesis of prostaglandins precursors, prostaglandins and their original fatty acids being involved in blood pressure regulation. SN - 0037-9026 UR - https://www.unboundmedicine.com/medline/citation/6241017/[In_vitro_study_of_delta_6__and_delta_5_desaturations_of_linoleic_and_dihomo_gamma_linolenic_acids_during_the_development_of_arterial_hypertension_as_a_function_of_age_in_spontaneously_hypertensive_rats__SHR__as_compared_to_normotensive_rats__WKY_]_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -