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Hypothalamic-pituitary evaluation in patients with galactorrhea-amenorrhea and hyperprolactinemia.
Obstet Gynecol. 1980 Jan; 55(1):1-7.OG

Abstract

Twenty-two women with galactorrhea and/or amenorrhea were evaluated. Thyroxine (T4), thyroid-stimulating hormone (TSH), and visual fields were normal. Hyperprolactinemia (22 to 440 ng/ml) was present in 19 patients. Evidence of tumor was found in 73.7% of the woemn, whereas 26.3% were classified as functional. Three patients with empty sella syndrome showed normal prolactin levels (12.2 to 18.5 ng/ml). There was a significant negative correlation between prolactin levels and follicle-stimulating hormone (FSH) (P less than 0.05), but not between prolactin and luteinizing hormone (LH) levels. Hypocyloidal polytomography was better than plain x-ray films in detecting early prolactin-secreting pituitary tumors (14 patients). Pituitary testing using an insulin tolerance test showed a statistically significant difference in human growth hormone (hGH) reserve between tumor and functional groups (P less than 0.0005), and none for the cortisol response. The 17-hydroxycorticoid response to metyrapone was impaired in the tumor patients (group 1). Serum prolactin levels showed various degrees of suppression with L-dopa (9.3 to 98.8%), with no significant difference between the various groups.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6243406

Citation

Badawy, S Z., et al. "Hypothalamic-pituitary Evaluation in Patients With Galactorrhea-amenorrhea and Hyperprolactinemia." Obstetrics and Gynecology, vol. 55, no. 1, 1980, pp. 1-7.
Badawy SZ, Nusbaum ML, Omar M. Hypothalamic-pituitary evaluation in patients with galactorrhea-amenorrhea and hyperprolactinemia. Obstet Gynecol. 1980;55(1):1-7.
Badawy, S. Z., Nusbaum, M. L., & Omar, M. (1980). Hypothalamic-pituitary evaluation in patients with galactorrhea-amenorrhea and hyperprolactinemia. Obstetrics and Gynecology, 55(1), 1-7.
Badawy SZ, Nusbaum ML, Omar M. Hypothalamic-pituitary Evaluation in Patients With Galactorrhea-amenorrhea and Hyperprolactinemia. Obstet Gynecol. 1980;55(1):1-7. PubMed PMID: 6243406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic-pituitary evaluation in patients with galactorrhea-amenorrhea and hyperprolactinemia. AU - Badawy,S Z, AU - Nusbaum,M L, AU - Omar,M, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 1 EP - 7 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 55 IS - 1 N2 - Twenty-two women with galactorrhea and/or amenorrhea were evaluated. Thyroxine (T4), thyroid-stimulating hormone (TSH), and visual fields were normal. Hyperprolactinemia (22 to 440 ng/ml) was present in 19 patients. Evidence of tumor was found in 73.7% of the woemn, whereas 26.3% were classified as functional. Three patients with empty sella syndrome showed normal prolactin levels (12.2 to 18.5 ng/ml). There was a significant negative correlation between prolactin levels and follicle-stimulating hormone (FSH) (P less than 0.05), but not between prolactin and luteinizing hormone (LH) levels. Hypocyloidal polytomography was better than plain x-ray films in detecting early prolactin-secreting pituitary tumors (14 patients). Pituitary testing using an insulin tolerance test showed a statistically significant difference in human growth hormone (hGH) reserve between tumor and functional groups (P less than 0.0005), and none for the cortisol response. The 17-hydroxycorticoid response to metyrapone was impaired in the tumor patients (group 1). Serum prolactin levels showed various degrees of suppression with L-dopa (9.3 to 98.8%), with no significant difference between the various groups. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/6243406/Hypothalamic_pituitary_evaluation_in_patients_with_galactorrhea_amenorrhea_and_hyperprolactinemia_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6243406.ui DB - PRIME DP - Unbound Medicine ER -