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Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man.
J Clin Invest. 1980 Mar; 65(3):682-9.JCI

Abstract

THE PRESENT STUDIES WERE UNDERTAKEN TO ASSESS THE ADRENERGIC MECHANISMS BY WHICH EPINEPHRINE STIMULATES GLUCOSE PRODUCTION AND SUPPRESSES GLUCOSE CLEARANCE IN MAN: epinephrine (50 ng/kg per min) was infused for 180 min alone and during either alpha (phentolamine) or beta (propranolol)-adrenergic blockade in normal subjects under conditions in which plasma insulin, glucagon, and glucose were maintained at comparable levels by infusion of somatostatin (100 mug/h), insulin (0.2 mU/kg per min), and variable amounts of glucose. In additional experiments, to control for the effects of the hyperglycemia caused by epinephrine, variable amounts of glucose without epinephrine were infused along with somatostatin and insulin to produce hyperglycemia comparable with that observed during infusion of epinephrine. This glucose infusion suppressed glucose production from basal rates of 1.8+/-0.1 to 0.0+/-0.1 mg/kg per min (P < 0.01), but did not alter glucose clearance. During infusion of epinephrine, glucose production increased transiently from a basal rate of 1.8+/-0.1 to a maximum of 3.0+/-0.2 mg/kg per min (P < 0.01) at min 30, and returned to near basal rates at min 180 (1.9+/-0.1 mg/kg per min). Glucose clearance decreased from a basal rate of 2.0+/-0.1 to 1.5+/-0.2 ml/kg per min at the end of the epinephrine infusion (P < 0.01). Infusion of phentolamine did not alter these effects of epinephrine on glucose production and clearance. In contrast, infusion of propranolol completely prevented the suppression of glucose clearance by epinephrine, and inhibited the stimulation of glucose production by epinephrine by 80+/-6% (P < 0.001). These results indicate that, under conditions in which plasma glucose, insulin, and glucagon are maintained constant, epinephrine stimulates glucose production and inhibits glucose clearance in man predominantly by beta adrenergic mechanisms.

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Authors

Rizza RA
No affiliation info available
Cryer PE
No affiliation info available
Haymond MW
No affiliation info available
Gerich JE
No affiliation info available

MeSH

AdultBlood GlucoseEpinephrineGlucagonHumansHyperglycemiaInsulinMalePhentolaminePropranololReceptors, AdrenergicReceptors, Adrenergic, beta

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6243675

Citation

Rizza, R A., et al. "Adrenergic Mechanisms for the Effects of Epinephrine On Glucose Production and Clearance in Man." The Journal of Clinical Investigation, vol. 65, no. 3, 1980, pp. 682-9.
Rizza RA, Cryer PE, Haymond MW, et al. Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest. 1980;65(3):682-9.
Rizza, R. A., Cryer, P. E., Haymond, M. W., & Gerich, J. E. (1980). Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. The Journal of Clinical Investigation, 65(3), 682-9.
Rizza RA, et al. Adrenergic Mechanisms for the Effects of Epinephrine On Glucose Production and Clearance in Man. J Clin Invest. 1980;65(3):682-9. PubMed PMID: 6243675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. AU - Rizza,R A, AU - Cryer,P E, AU - Haymond,M W, AU - Gerich,J E, PY - 1980/3/1/pubmed PY - 1980/3/1/medline PY - 1980/3/1/entrez SP - 682 EP - 9 JF - The Journal of clinical investigation JO - J Clin Invest VL - 65 IS - 3 N2 - THE PRESENT STUDIES WERE UNDERTAKEN TO ASSESS THE ADRENERGIC MECHANISMS BY WHICH EPINEPHRINE STIMULATES GLUCOSE PRODUCTION AND SUPPRESSES GLUCOSE CLEARANCE IN MAN: epinephrine (50 ng/kg per min) was infused for 180 min alone and during either alpha (phentolamine) or beta (propranolol)-adrenergic blockade in normal subjects under conditions in which plasma insulin, glucagon, and glucose were maintained at comparable levels by infusion of somatostatin (100 mug/h), insulin (0.2 mU/kg per min), and variable amounts of glucose. In additional experiments, to control for the effects of the hyperglycemia caused by epinephrine, variable amounts of glucose without epinephrine were infused along with somatostatin and insulin to produce hyperglycemia comparable with that observed during infusion of epinephrine. This glucose infusion suppressed glucose production from basal rates of 1.8+/-0.1 to 0.0+/-0.1 mg/kg per min (P < 0.01), but did not alter glucose clearance. During infusion of epinephrine, glucose production increased transiently from a basal rate of 1.8+/-0.1 to a maximum of 3.0+/-0.2 mg/kg per min (P < 0.01) at min 30, and returned to near basal rates at min 180 (1.9+/-0.1 mg/kg per min). Glucose clearance decreased from a basal rate of 2.0+/-0.1 to 1.5+/-0.2 ml/kg per min at the end of the epinephrine infusion (P < 0.01). Infusion of phentolamine did not alter these effects of epinephrine on glucose production and clearance. In contrast, infusion of propranolol completely prevented the suppression of glucose clearance by epinephrine, and inhibited the stimulation of glucose production by epinephrine by 80+/-6% (P < 0.001). These results indicate that, under conditions in which plasma glucose, insulin, and glucagon are maintained constant, epinephrine stimulates glucose production and inhibits glucose clearance in man predominantly by beta adrenergic mechanisms. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/6243675/Adrenergic_mechanisms_for_the_effects_of_epinephrine_on_glucose_production_and_clearance_in_man_ L2 - https://doi.org/10.1172/JCI109714 DB - PRIME DP - Unbound Medicine ER -