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Local IgA-class antibodies against respiratory viruses in middle ear and nasopharyngeal secretions of children with secretory otitis media.
Laryngoscope. 1980 Feb; 90(2):304-11.L

Abstract

The presence of antibodies against some important respiratory viruses in the middle ear and nasopharyngeal secretions of 52 children with secretory otitis media (SOM) was investigated in order to find out about the role of these viruses in the development of SOM. The method employed was a sensitive radioimmunoassay test. Antibodies to adeno, syncytial, and parainfluenza 3 viruses were detected in about 50%, 50% and 20% of the patients, respectively. In eight patients the middle ear secretion/nasopharyngeal secretion titer ratio of antibodies to one virus was selectively increased in comparison with the other viruses tested, indicating an active local production of specific antibodies in the middle ear. Further studies are required to determine the cause of such an active antibody synthesis and its possible role in the etiopathogenesis of SOM.

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Authors

Meurman OH
No affiliation info available
Sarkkinen HK
No affiliation info available
Puhakka HJ
No affiliation info available
Virolainen ES
No affiliation info available
Meurman OH
No affiliation info available

MeSH

AdenoviridaeAdolescentAntibodies, ViralChildChild, PreschoolExudates and TransudatesFemaleHumansImmunoglobulin AInfantInfluenza A virusMaleNasopharynxOtitis MediaOtitis Media with EffusionRadioimmunoassayRespiratory Syncytial VirusesRespirovirus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6243732

Citation

Meurman, O H., et al. "Local IgA-class Antibodies Against Respiratory Viruses in Middle Ear and Nasopharyngeal Secretions of Children With Secretory Otitis Media." The Laryngoscope, vol. 90, no. 2, 1980, pp. 304-11.
Meurman OH, Sarkkinen HK, Puhakka HJ, et al. Local IgA-class antibodies against respiratory viruses in middle ear and nasopharyngeal secretions of children with secretory otitis media. Laryngoscope. 1980;90(2):304-11.
Meurman, O. H., Sarkkinen, H. K., Puhakka, H. J., Virolainen, E. S., & Meurman, O. H. (1980). Local IgA-class antibodies against respiratory viruses in middle ear and nasopharyngeal secretions of children with secretory otitis media. The Laryngoscope, 90(2), 304-11.
Meurman OH, et al. Local IgA-class Antibodies Against Respiratory Viruses in Middle Ear and Nasopharyngeal Secretions of Children With Secretory Otitis Media. Laryngoscope. 1980;90(2):304-11. PubMed PMID: 6243732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local IgA-class antibodies against respiratory viruses in middle ear and nasopharyngeal secretions of children with secretory otitis media. AU - Meurman,O H, AU - Sarkkinen,H K, AU - Puhakka,H J, AU - Virolainen,E S, AU - Meurman,O H, PY - 1980/2/1/pubmed PY - 1980/2/1/medline PY - 1980/2/1/entrez SP - 304 EP - 11 JF - The Laryngoscope JO - Laryngoscope VL - 90 IS - 2 N2 - The presence of antibodies against some important respiratory viruses in the middle ear and nasopharyngeal secretions of 52 children with secretory otitis media (SOM) was investigated in order to find out about the role of these viruses in the development of SOM. The method employed was a sensitive radioimmunoassay test. Antibodies to adeno, syncytial, and parainfluenza 3 viruses were detected in about 50%, 50% and 20% of the patients, respectively. In eight patients the middle ear secretion/nasopharyngeal secretion titer ratio of antibodies to one virus was selectively increased in comparison with the other viruses tested, indicating an active local production of specific antibodies in the middle ear. Further studies are required to determine the cause of such an active antibody synthesis and its possible role in the etiopathogenesis of SOM. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/6243732/Local_IgA_class_antibodies_against_respiratory_viruses_in_middle_ear_and_nasopharyngeal_secretions_of_children_with_secretory_otitis_media_ L2 - https://doi.org/10.1288/00005537-198002000-00016 DB - PRIME DP - Unbound Medicine ER -