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Reduction of hippocampal acetylcholine turnover in rats treated with (-)-delta 8-tetrahydrocannabinol and its 1',2'-dimethyl-heptyl homolog.
Brain Res. 1980 Aug 18; 195(2):445-52.BR

Abstract

The effects of (-)-delta 8-tetrahydrocannabinol (THC), (+)-delta 8-THC, and the dimethyl-heptyl (DMH) homolog of (-)-delta 8-THC (delta 8-THC-DMH) have been compared with the action of (-)-delta 9-THC on the turnover rate of acetylcholine in various brain areas. The data demonstrate that (-)-delta 8-THC-DMH, (-)-delta 9-THC and (-)- delta 8-THC all specifically reduce ther turnover rate of acetylcholine in the hippocampus in a dose-dependent manner ((-)-delta 8-THC-DMH > (-)-delta 9-THC > (-)-delta 8-THC) without altering the acetylcholine or choline content (except for high doses of (-)-delta 8-THC-DMH). The (+)-isomer of delta 8-THC fails to change any cholinergic parameter. The selectivity of action suggests that the tetrahydrocannabinoids may activate specific transmitter receptors which indirectly modulate the activity of the cholinergic neurons in the septal-hippocampal pathway.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6249445

Citation

Revuelta, A V., et al. "Reduction of Hippocampal Acetylcholine Turnover in Rats Treated With (-)-delta 8-tetrahydrocannabinol and Its 1',2'-dimethyl-heptyl Homolog." Brain Research, vol. 195, no. 2, 1980, pp. 445-52.
Revuelta AV, Cheney DL, Costa E, et al. Reduction of hippocampal acetylcholine turnover in rats treated with (-)-delta 8-tetrahydrocannabinol and its 1',2'-dimethyl-heptyl homolog. Brain Res. 1980;195(2):445-52.
Revuelta, A. V., Cheney, D. L., Costa, E., Lander, N., & Mechoulam, R. (1980). Reduction of hippocampal acetylcholine turnover in rats treated with (-)-delta 8-tetrahydrocannabinol and its 1',2'-dimethyl-heptyl homolog. Brain Research, 195(2), 445-52.
Revuelta AV, et al. Reduction of Hippocampal Acetylcholine Turnover in Rats Treated With (-)-delta 8-tetrahydrocannabinol and Its 1',2'-dimethyl-heptyl Homolog. Brain Res. 1980 Aug 18;195(2):445-52. PubMed PMID: 6249445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of hippocampal acetylcholine turnover in rats treated with (-)-delta 8-tetrahydrocannabinol and its 1',2'-dimethyl-heptyl homolog. AU - Revuelta,A V, AU - Cheney,D L, AU - Costa,E, AU - Lander,N, AU - Mechoulam,R, PY - 1980/8/18/pubmed PY - 1980/8/18/medline PY - 1980/8/18/entrez SP - 445 EP - 52 JF - Brain research JO - Brain Res VL - 195 IS - 2 N2 - The effects of (-)-delta 8-tetrahydrocannabinol (THC), (+)-delta 8-THC, and the dimethyl-heptyl (DMH) homolog of (-)-delta 8-THC (delta 8-THC-DMH) have been compared with the action of (-)-delta 9-THC on the turnover rate of acetylcholine in various brain areas. The data demonstrate that (-)-delta 8-THC-DMH, (-)-delta 9-THC and (-)- delta 8-THC all specifically reduce ther turnover rate of acetylcholine in the hippocampus in a dose-dependent manner ((-)-delta 8-THC-DMH > (-)-delta 9-THC > (-)-delta 8-THC) without altering the acetylcholine or choline content (except for high doses of (-)-delta 8-THC-DMH). The (+)-isomer of delta 8-THC fails to change any cholinergic parameter. The selectivity of action suggests that the tetrahydrocannabinoids may activate specific transmitter receptors which indirectly modulate the activity of the cholinergic neurons in the septal-hippocampal pathway. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/6249445/Reduction_of_hippocampal_acetylcholine_turnover_in_rats_treated_with_____delta_8_tetrahydrocannabinol_and_its_1'2'_dimethyl_heptyl_homolog_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(80)90078-5 DB - PRIME DP - Unbound Medicine ER -