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Regulation of renal adenylate cyclase by parathyroid hormone.
Am J Physiol 1980; 239(6):E396-400AJ

Abstract

This study reports the effects of the removal of endogenous PTH by thyroparathyroidectomy (TPTX) on the recovery of the reduced renal cAMP response to parathyroid hormone (PTH) in rats with chronically elevated PTH secondary to diets deficient in either vitamin D or calcium. After TPTX and infusion with a calcium-glucose solution of the vitamin D-deficient rat, calcium and PTH fell from 5.8 mg/dl and 2,509 pg/ml, respectively, to 4.8 mg/dl and 160 pg/ml at 48 h. There was a partial restoration of response to PTH, assessed by assay of renal cortical adenylate cyclase activity from 64% of control activity prior to TPTX to 84% of control activity at 48 h. When rats fed the diet deficient in calcium were TPTX, serum PTH fell rapidly from 2,811 to 200 pg/ml at 5 h with no further change at 21 h, whereas calcium did not change (5.3 mg/dl). PTH-dependent adenylate cyclase activity increased from 59% of control activity prior to TPTX to 87% at 5 h and 100% of control activity at 21 h after TPTX. Each diet produced similar increases in the serum level of immunoreactive PTH, and the rate of disappearance of the circulating hormone after TPTX was also similar for both groups of rats. The data indicate a slow, partial recovery of the enzyme response to PTH after TPTX of the vitamin D-deficient rat over the time period studied, whereas the recovery was rapid and complete in rats fed the diet deficient in calcium.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6255802

Citation

Carnes, D L., et al. "Regulation of Renal Adenylate Cyclase By Parathyroid Hormone." The American Journal of Physiology, vol. 239, no. 6, 1980, pp. E396-400.
Carnes DL, Nickols GA, Anast CS, et al. Regulation of renal adenylate cyclase by parathyroid hormone. Am J Physiol. 1980;239(6):E396-400.
Carnes, D. L., Nickols, G. A., Anast, C. S., & Forte, L. R. (1980). Regulation of renal adenylate cyclase by parathyroid hormone. The American Journal of Physiology, 239(6), pp. E396-400.
Carnes DL, et al. Regulation of Renal Adenylate Cyclase By Parathyroid Hormone. Am J Physiol. 1980;239(6):E396-400. PubMed PMID: 6255802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of renal adenylate cyclase by parathyroid hormone. AU - Carnes,D L, AU - Nickols,G A, AU - Anast,C S, AU - Forte,L R, PY - 1980/12/1/pubmed PY - 1980/12/1/medline PY - 1980/12/1/entrez SP - E396 EP - 400 JF - The American journal of physiology JO - Am. J. Physiol. VL - 239 IS - 6 N2 - This study reports the effects of the removal of endogenous PTH by thyroparathyroidectomy (TPTX) on the recovery of the reduced renal cAMP response to parathyroid hormone (PTH) in rats with chronically elevated PTH secondary to diets deficient in either vitamin D or calcium. After TPTX and infusion with a calcium-glucose solution of the vitamin D-deficient rat, calcium and PTH fell from 5.8 mg/dl and 2,509 pg/ml, respectively, to 4.8 mg/dl and 160 pg/ml at 48 h. There was a partial restoration of response to PTH, assessed by assay of renal cortical adenylate cyclase activity from 64% of control activity prior to TPTX to 84% of control activity at 48 h. When rats fed the diet deficient in calcium were TPTX, serum PTH fell rapidly from 2,811 to 200 pg/ml at 5 h with no further change at 21 h, whereas calcium did not change (5.3 mg/dl). PTH-dependent adenylate cyclase activity increased from 59% of control activity prior to TPTX to 87% at 5 h and 100% of control activity at 21 h after TPTX. Each diet produced similar increases in the serum level of immunoreactive PTH, and the rate of disappearance of the circulating hormone after TPTX was also similar for both groups of rats. The data indicate a slow, partial recovery of the enzyme response to PTH after TPTX of the vitamin D-deficient rat over the time period studied, whereas the recovery was rapid and complete in rats fed the diet deficient in calcium. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/6255802/Regulation_of_renal_adenylate_cyclase_by_parathyroid_hormone_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpendo.1980.239.6.E396?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -