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Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator.
Science. 1981 Feb 06; 211(4482):590-3.Sci

Abstract

When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6256855

Citation

Holick, M F., et al. "Regulation of Cutaneous Previtamin D3 Photosynthesis in Man: Skin Pigment Is Not an Essential Regulator." Science (New York, N.Y.), vol. 211, no. 4482, 1981, pp. 590-3.
Holick MF, MacLaughlin JA, Doppelt SH. Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science. 1981;211(4482):590-3.
Holick, M. F., MacLaughlin, J. A., & Doppelt, S. H. (1981). Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science (New York, N.Y.), 211(4482), 590-3.
Holick MF, MacLaughlin JA, Doppelt SH. Regulation of Cutaneous Previtamin D3 Photosynthesis in Man: Skin Pigment Is Not an Essential Regulator. Science. 1981 Feb 6;211(4482):590-3. PubMed PMID: 6256855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. AU - Holick,M F, AU - MacLaughlin,J A, AU - Doppelt,S H, PY - 1981/2/6/pubmed PY - 1981/2/6/medline PY - 1981/2/6/entrez SP - 590 EP - 3 JF - Science (New York, N.Y.) JO - Science VL - 211 IS - 4482 N2 - When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/6256855/Regulation_of_cutaneous_previtamin_D3_photosynthesis_in_man:_skin_pigment_is_not_an_essential_regulator_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=6256855 DB - PRIME DP - Unbound Medicine ER -