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Labetalol in long-term treatment of hypertension.
Br J Clin Pharmacol. 1976 Aug; 3(4 Suppl 3):743-50.BJ

Abstract

1 Labetalol, a beta- and alpha-adrenoreceptor-blocking drug, has been used in the treatment of hypertension in a total of 32 patients for over 4.5 yr, 14 patients for 3 yr or more. 2 Labetalol seems to have a similarly potency of methyldopa and the adrenergic neurone-blocking drugs. 3 Postural hypotension was only observed at doses over 2 g/d. It was the reason for stopping treatment in two patients. 4 Dosage varied; average 889 mg/d, range 75-3,200 mg. Tolerance did not develop. 5 Side-effects led to drug withdrawal in four patients

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Authors

Prichard BN
No affiliation info available
Boakes AJ
No affiliation info available

MeSH

Adrenergic AgentsAdrenergic beta-AntagonistsAdultAgedDose-Response Relationship, DrugDrug Administration ScheduleDrug EvaluationEthanolaminesFemaleHumansHypertensionLabetalolMaleMethyldopaMiddle AgedPosture

Pub Type(s)

Journal Article

Language

eng

PubMed ID

62582

Citation

Prichard, B N., and A J. Boakes. "Labetalol in Long-term Treatment of Hypertension." British Journal of Clinical Pharmacology, vol. 3, no. 4 Suppl 3, 1976, pp. 743-50.
Prichard BN, Boakes AJ. Labetalol in long-term treatment of hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):743-50.
Prichard, B. N., & Boakes, A. J. (1976). Labetalol in long-term treatment of hypertension. British Journal of Clinical Pharmacology, 3(4 Suppl 3), 743-50.
Prichard BN, Boakes AJ. Labetalol in Long-term Treatment of Hypertension. Br J Clin Pharmacol. 1976;3(4 Suppl 3):743-50. PubMed PMID: 62582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Labetalol in long-term treatment of hypertension. AU - Prichard,B N, AU - Boakes,A J, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 743 EP - 50 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 3 IS - 4 Suppl 3 N2 - 1 Labetalol, a beta- and alpha-adrenoreceptor-blocking drug, has been used in the treatment of hypertension in a total of 32 patients for over 4.5 yr, 14 patients for 3 yr or more. 2 Labetalol seems to have a similarly potency of methyldopa and the adrenergic neurone-blocking drugs. 3 Postural hypotension was only observed at doses over 2 g/d. It was the reason for stopping treatment in two patients. 4 Dosage varied; average 889 mg/d, range 75-3,200 mg. Tolerance did not develop. 5 Side-effects led to drug withdrawal in four patients SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/62582/Labetalol_in_long_term_treatment_of_hypertension_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1976&volume=3&issue=4 Suppl 3&spage=743 DB - PRIME DP - Unbound Medicine ER -