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The effects of inhibition of the strial Na+-K+-activated ATPase by perilymphatic ouabain in the guinea pig.
Acta Otolaryngol. 1980 Sep-Oct; 90(3-4):219-29.AO

Abstract

The endolymphatic effects of perilymphatic ouabain (2 X 10(-3) M) were followed in 3 guinea pigs using ion-sensitive micro-electrodes, enabling a Na+-related permeability increase to be identified. Investigation of the strial ultrastructural changes in 11 more animals revealed early swelling of the marginal cells, while the intermediate and basal cells became shrunken with characteristically dark-staining cytoplasm. The subsequent cellular alterations were complex. The findings suggest that a major function of the Na+-K+-activated ATPase is preservation of the normal intracellular environment, inhibition resulting in widespread indirect effects. General measures of strial function, consequently, do not document just ATPase inhibition.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6258382

Citation

Bosher, S K.. "The Effects of Inhibition of the Strial Na+-K+-activated ATPase By Perilymphatic Ouabain in the Guinea Pig." Acta Oto-laryngologica, vol. 90, no. 3-4, 1980, pp. 219-29.
Bosher SK. The effects of inhibition of the strial Na+-K+-activated ATPase by perilymphatic ouabain in the guinea pig. Acta Otolaryngol. 1980;90(3-4):219-29.
Bosher, S. K. (1980). The effects of inhibition of the strial Na+-K+-activated ATPase by perilymphatic ouabain in the guinea pig. Acta Oto-laryngologica, 90(3-4), 219-29.
Bosher SK. The Effects of Inhibition of the Strial Na+-K+-activated ATPase By Perilymphatic Ouabain in the Guinea Pig. Acta Otolaryngol. 1980 Sep-Oct;90(3-4):219-29. PubMed PMID: 6258382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of inhibition of the strial Na+-K+-activated ATPase by perilymphatic ouabain in the guinea pig. A1 - Bosher,S K, PY - 1980/9/1/pubmed PY - 1980/9/1/medline PY - 1980/9/1/entrez SP - 219 EP - 29 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 90 IS - 3-4 N2 - The endolymphatic effects of perilymphatic ouabain (2 X 10(-3) M) were followed in 3 guinea pigs using ion-sensitive micro-electrodes, enabling a Na+-related permeability increase to be identified. Investigation of the strial ultrastructural changes in 11 more animals revealed early swelling of the marginal cells, while the intermediate and basal cells became shrunken with characteristically dark-staining cytoplasm. The subsequent cellular alterations were complex. The findings suggest that a major function of the Na+-K+-activated ATPase is preservation of the normal intracellular environment, inhibition resulting in widespread indirect effects. General measures of strial function, consequently, do not document just ATPase inhibition. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/6258382/The_effects_of_inhibition_of_the_strial_Na+_K+_activated_ATPase_by_perilymphatic_ouabain_in_the_guinea_pig_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016488009131718 DB - PRIME DP - Unbound Medicine ER -