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Islet cell tumors and the ulcerogenic syndrome.
Monogr Pathol. 1980; 21:177-84.MP

Abstract

It has now been well established that the ulcerogenic syndrome associated with non-beta islet cell tumors of the pancreas is due to excess gastrin release and consequent marked gastric acid hypersecretion. The clinical manifestations may be similar to, but are often more severe and recurrent than, common peptic ulcer. The diagnosis of gastrinoma in patients with this clinical syndrome can be established principally by demonstration of fasting hypergastrinemia, and by application of provocative tests with measurement of serum gastrin in response to intravenous calcium infusion, intravenous secretin injection and feeding of a standard meal. Gastrinomas are usually located within the pancreas, are often multifocal and metastatic, but may be primary in non-pancreatic sites. There is substantial heterogeneity in the molecular forms of circulating and gastrinoma gastrin. Although hypergastrinemia is characteristic of gastrinoma, serum gastrin levels may be increased in disorders other than gastrinoma. Techniques are available to document the presence of gastrin in islet cell tumors and, thereby, to establish these as gastrinomas.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6261121

Citation

McGuigan, J E.. "Islet Cell Tumors and the Ulcerogenic Syndrome." Monographs in Pathology, vol. 21, 1980, pp. 177-84.
McGuigan JE. Islet cell tumors and the ulcerogenic syndrome. Monogr Pathol. 1980;21:177-84.
McGuigan, J. E. (1980). Islet cell tumors and the ulcerogenic syndrome. Monographs in Pathology, 21, 177-84.
McGuigan JE. Islet Cell Tumors and the Ulcerogenic Syndrome. Monogr Pathol. 1980;21:177-84. PubMed PMID: 6261121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Islet cell tumors and the ulcerogenic syndrome. A1 - McGuigan,J E, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 177 EP - 84 JF - Monographs in pathology JO - Monogr Pathol VL - 21 N2 - It has now been well established that the ulcerogenic syndrome associated with non-beta islet cell tumors of the pancreas is due to excess gastrin release and consequent marked gastric acid hypersecretion. The clinical manifestations may be similar to, but are often more severe and recurrent than, common peptic ulcer. The diagnosis of gastrinoma in patients with this clinical syndrome can be established principally by demonstration of fasting hypergastrinemia, and by application of provocative tests with measurement of serum gastrin in response to intravenous calcium infusion, intravenous secretin injection and feeding of a standard meal. Gastrinomas are usually located within the pancreas, are often multifocal and metastatic, but may be primary in non-pancreatic sites. There is substantial heterogeneity in the molecular forms of circulating and gastrinoma gastrin. Although hypergastrinemia is characteristic of gastrinoma, serum gastrin levels may be increased in disorders other than gastrinoma. Techniques are available to document the presence of gastrin in islet cell tumors and, thereby, to establish these as gastrinomas. SN - 0077-0922 UR - https://www.unboundmedicine.com/medline/citation/6261121/Islet_cell_tumors_and_the_ulcerogenic_syndrome_ DB - PRIME DP - Unbound Medicine ER -