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Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol.
Arch Int Pharmacodyn Ther. 1981 Jan; 249(1):137-46.AI

Abstract

Rats, trained to discriminate between delta 9-THC (5 mg/kg) and a control solution, using a T-maze, were submitted to generalization tests wih delta 9-THC (2.5 and 1.25 mg/kg), CBD (40 mg/kg) and the mixtures of delta 9-THC (5 and 1.25 mg/kg) with CBD (40 mg/kg). Doses of delta 9-THC smaller than the training dose, produced a progressive reduction in the number of correct responses together with a decrease in the running time. The choice made by the animals under the effect of CBD (40 mg/kg) did not differ from that of the animals given the control solution but their running time was significantly longer. The mixtures of CBD (40 mg/kg) with delta 9-THC (5 and 1.25 mg/kg) produced approximately 50% response to both sides of the maze, and with run times greater than those observed with delta 9-THC (5 mg/kg). The results suggest that the simultaneous administration of the two cannabinoids might produce a qualitative stimulus different from that produced by delta 9-THC alone.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6261703

Citation

Zuardi, A W., et al. "Characteristics of the Stimulus Produced By the Mixture of Cannabidiol With Delta 9-tetrahydrocannabinol." Archives Internationales De Pharmacodynamie Et De Therapie, vol. 249, no. 1, 1981, pp. 137-46.
Zuardi AW, Finkelfarb E, Bueno OF, et al. Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Arch Int Pharmacodyn Ther. 1981;249(1):137-46.
Zuardi, A. W., Finkelfarb, E., Bueno, O. F., Musty, R. E., & Karniol, I. G. (1981). Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Archives Internationales De Pharmacodynamie Et De Therapie, 249(1), 137-46.
Zuardi AW, et al. Characteristics of the Stimulus Produced By the Mixture of Cannabidiol With Delta 9-tetrahydrocannabinol. Arch Int Pharmacodyn Ther. 1981;249(1):137-46. PubMed PMID: 6261703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. AU - Zuardi,A W, AU - Finkelfarb,E, AU - Bueno,O F, AU - Musty,R E, AU - Karniol,I G, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 137 EP - 46 JF - Archives internationales de pharmacodynamie et de therapie JO - Arch Int Pharmacodyn Ther VL - 249 IS - 1 N2 - Rats, trained to discriminate between delta 9-THC (5 mg/kg) and a control solution, using a T-maze, were submitted to generalization tests wih delta 9-THC (2.5 and 1.25 mg/kg), CBD (40 mg/kg) and the mixtures of delta 9-THC (5 and 1.25 mg/kg) with CBD (40 mg/kg). Doses of delta 9-THC smaller than the training dose, produced a progressive reduction in the number of correct responses together with a decrease in the running time. The choice made by the animals under the effect of CBD (40 mg/kg) did not differ from that of the animals given the control solution but their running time was significantly longer. The mixtures of CBD (40 mg/kg) with delta 9-THC (5 and 1.25 mg/kg) produced approximately 50% response to both sides of the maze, and with run times greater than those observed with delta 9-THC (5 mg/kg). The results suggest that the simultaneous administration of the two cannabinoids might produce a qualitative stimulus different from that produced by delta 9-THC alone. SN - 0003-9780 UR - https://www.unboundmedicine.com/medline/citation/6261703/Characteristics_of_the_stimulus_produced_by_the_mixture_of_cannabidiol_with_delta_9_tetrahydrocannabinol_ DB - PRIME DP - Unbound Medicine ER -