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[Development of biological psychiatric depression research (author's transl)].
MMW Munch Med Wochenschr. 1981 May 08; 123(19):793-4.MM

Abstract

The discovery of the anti-depressive effects of imipramine and the MAO inhibitors, associated with the occasional depressions occurring during reserpine treatment was the starting point of modern research into depression. The concern with the neurochemical actions of these substances led to putting forth the noradrenaline and serotonin hypothesis of depression in the mid-60s. According to this, there is supposed to be a deficiency of noradrenaline and/or serotonin at the nerve endings in depression. This amine deficiency hypothesis has not been proved as yet in spite of intensive neurobiological research. Clinical as well as animal experiments in depressive patients with antidepressive drugs have led to the assumption that, in "endogenous" depression particularly, but also for the antidepressive mechanisms, alpha- and beta-adrenergic receptor changes play an important part.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6262640

Citation

Matussek, N. "[Development of Biological Psychiatric Depression Research (author's Transl)]." MMW, Munchener Medizinische Wochenschrift, vol. 123, no. 19, 1981, pp. 793-4.
Matussek N. [Development of biological psychiatric depression research (author's transl)]. MMW Munch Med Wochenschr. 1981;123(19):793-4.
Matussek, N. (1981). [Development of biological psychiatric depression research (author's transl)]. MMW, Munchener Medizinische Wochenschrift, 123(19), 793-4.
Matussek N. [Development of Biological Psychiatric Depression Research (author's Transl)]. MMW Munch Med Wochenschr. 1981 May 8;123(19):793-4. PubMed PMID: 6262640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Development of biological psychiatric depression research (author's transl)]. A1 - Matussek,N, PY - 1981/5/8/pubmed PY - 1981/5/8/medline PY - 1981/5/8/entrez SP - 793 EP - 4 JF - MMW, Munchener medizinische Wochenschrift JO - MMW Munch Med Wochenschr VL - 123 IS - 19 N2 - The discovery of the anti-depressive effects of imipramine and the MAO inhibitors, associated with the occasional depressions occurring during reserpine treatment was the starting point of modern research into depression. The concern with the neurochemical actions of these substances led to putting forth the noradrenaline and serotonin hypothesis of depression in the mid-60s. According to this, there is supposed to be a deficiency of noradrenaline and/or serotonin at the nerve endings in depression. This amine deficiency hypothesis has not been proved as yet in spite of intensive neurobiological research. Clinical as well as animal experiments in depressive patients with antidepressive drugs have led to the assumption that, in "endogenous" depression particularly, but also for the antidepressive mechanisms, alpha- and beta-adrenergic receptor changes play an important part. SN - 0341-3098 UR - https://www.unboundmedicine.com/medline/citation/6262640/[Development_of_biological_psychiatric_depression_research__author's_transl_]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -