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Gluten-free diet in dermatitis herpetiformis. II. Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls.
Br J Dermatol. 1978 Jan; 98(1):69-78.BJ

Abstract

Twelve patients with dermatitis herpetiformis whose skin condition responded to a gluten-free diet (GFD) were re-examined after diet treatment. The findings were compared with those in matched patients on a normal diet. Jejunal histology revealed morphological improvement in every patient on a GFD whereas all patients on a normal diet continued to have villous atrophy. Intra-epithelial lymphocyte counts were normal in 8 patients on a GFD in contrast to one on a normal diet. Immunofluorescence examination of the jejunal mucosa revealed that the numbers of cells containing IgA and IgM were increased significantly in the normal diet group. The figures were lower in the GFD group but these also exceeded the values in the controls. IgA deposits were found in the uninvolved skin of every patient irrespective of the diet treatment, but the fluorescence seemed to be less intense in patients on a GFD. A clear difference was found in the occurrence of C3 deposits in the uninvolved skin. Three patients on a GFD had C3 deposits; two of these did not follow a strict diet. However C3 was found in 8 patients on a normal diet. Circulating dietary and auto-antibodies were found in two patients on a GFD and in 9 on a normal diet. Serum immunoglobulin (IgG, IgA, IgM) and complement (C3, C4) levels were within normal limits in both patient groups.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

626715

Citation

Reunala, T. "Gluten-free Diet in Dermatitis Herpetiformis. II. Morphological and Immunological Findings in the Skin and Small Intestine of 12 Patients and Matched Controls." The British Journal of Dermatology, vol. 98, no. 1, 1978, pp. 69-78.
Reunala T. Gluten-free diet in dermatitis herpetiformis. II. Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls. Br J Dermatol. 1978;98(1):69-78.
Reunala, T. (1978). Gluten-free diet in dermatitis herpetiformis. II. Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls. The British Journal of Dermatology, 98(1), 69-78.
Reunala T. Gluten-free Diet in Dermatitis Herpetiformis. II. Morphological and Immunological Findings in the Skin and Small Intestine of 12 Patients and Matched Controls. Br J Dermatol. 1978;98(1):69-78. PubMed PMID: 626715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gluten-free diet in dermatitis herpetiformis. II. Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls. A1 - Reunala,T, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 69 EP - 78 JF - The British journal of dermatology JO - Br J Dermatol VL - 98 IS - 1 N2 - Twelve patients with dermatitis herpetiformis whose skin condition responded to a gluten-free diet (GFD) were re-examined after diet treatment. The findings were compared with those in matched patients on a normal diet. Jejunal histology revealed morphological improvement in every patient on a GFD whereas all patients on a normal diet continued to have villous atrophy. Intra-epithelial lymphocyte counts were normal in 8 patients on a GFD in contrast to one on a normal diet. Immunofluorescence examination of the jejunal mucosa revealed that the numbers of cells containing IgA and IgM were increased significantly in the normal diet group. The figures were lower in the GFD group but these also exceeded the values in the controls. IgA deposits were found in the uninvolved skin of every patient irrespective of the diet treatment, but the fluorescence seemed to be less intense in patients on a GFD. A clear difference was found in the occurrence of C3 deposits in the uninvolved skin. Three patients on a GFD had C3 deposits; two of these did not follow a strict diet. However C3 was found in 8 patients on a normal diet. Circulating dietary and auto-antibodies were found in two patients on a GFD and in 9 on a normal diet. Serum immunoglobulin (IgG, IgA, IgM) and complement (C3, C4) levels were within normal limits in both patient groups. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/626715/Gluten_free_diet_in_dermatitis_herpetiformis__II__Morphological_and_immunological_findings_in_the_skin_and_small_intestine_of_12_patients_and_matched_controls_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1978&volume=98&issue=1&spage=69 DB - PRIME DP - Unbound Medicine ER -