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Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis.
Psychopharmacology (Berl). 1981; 74(3):208-12.P

Abstract

delta 9-Tetrahydrocannabinol (delta 9-THC) was administered in a crossover design by smoking and IV injection to groups of heavy and light users of marihuana. Plasma concentrations of delta 9-THC were similar for the groups after IV injection of 5.0 mg delta 9-THC, but the AUC0-240 min showed a trend towards lower values for the heavy user group. To achieve a maximum desired "high", both groups smoked similar amounts (about 13 mg) of delta 9-THC. Heavy users tended to have higher plasma levels than light users. The systemic availability of smoked delta 9-THC was significantly higher for the heavy users (heavy users 23 +/- 16% vs 10 +/- 7% for light users). These results also indicate that heavy cannabis users smoke more efficiently than casual smokers. Both light and heavy users showed more clinical effect following IV administration than after smoking. The response of the heavy users, both with respect to effect on heart and "high", was quite comparable to that of light users. The present study does not suggest that tolerance readily develops in heavy users.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6267648

Citation

Lindgren, J E., et al. "Clinical Effects and Plasma Levels of Delta 9-tetrahydrocannabinol (delta 9-THC) in Heavy and Light Users of Cannabis." Psychopharmacology, vol. 74, no. 3, 1981, pp. 208-12.
Lindgren JE, Ohlsson A, Agurell S, et al. Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. Psychopharmacology (Berl). 1981;74(3):208-12.
Lindgren, J. E., Ohlsson, A., Agurell, S., Hollister, L., & Gillespie, H. (1981). Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. Psychopharmacology, 74(3), 208-12.
Lindgren JE, et al. Clinical Effects and Plasma Levels of Delta 9-tetrahydrocannabinol (delta 9-THC) in Heavy and Light Users of Cannabis. Psychopharmacology (Berl). 1981;74(3):208-12. PubMed PMID: 6267648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. AU - Lindgren,J E, AU - Ohlsson,A, AU - Agurell,S, AU - Hollister,L, AU - Gillespie,H, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 208 EP - 12 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 74 IS - 3 N2 - delta 9-Tetrahydrocannabinol (delta 9-THC) was administered in a crossover design by smoking and IV injection to groups of heavy and light users of marihuana. Plasma concentrations of delta 9-THC were similar for the groups after IV injection of 5.0 mg delta 9-THC, but the AUC0-240 min showed a trend towards lower values for the heavy user group. To achieve a maximum desired "high", both groups smoked similar amounts (about 13 mg) of delta 9-THC. Heavy users tended to have higher plasma levels than light users. The systemic availability of smoked delta 9-THC was significantly higher for the heavy users (heavy users 23 +/- 16% vs 10 +/- 7% for light users). These results also indicate that heavy cannabis users smoke more efficiently than casual smokers. Both light and heavy users showed more clinical effect following IV administration than after smoking. The response of the heavy users, both with respect to effect on heart and "high", was quite comparable to that of light users. The present study does not suggest that tolerance readily develops in heavy users. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/6267648/Clinical_effects_and_plasma_levels_of_delta_9_tetrahydrocannabinol__delta_9_THC__in_heavy_and_light_users_of_cannabis_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6267648 DB - PRIME DP - Unbound Medicine ER -