Tags

Type your tag names separated by a space and hit enter

Involvement of brain monoamines in the delta-9-tetrahydrocannabinol-induced reduction of hippocampal choline uptake.
J Neurochem. 1981 Sep; 37(3):788-91.JN

Abstract

The role of monoamines in the transsynaptic reduction of neuronal activity produced by delta 9-tetrahydrocannabinol (delta 9-THC) in the septal-hippocampal cholinergic pathway has been investigated. Serotonergic afferents were chemically lesioned by unilateral infusion of 5,7-dihydroxytryptamine. Noradrenergic and dopaminergic inputs were selectively deleted by unilateral infusion of 6-hydroxydopamine into appropriate anatomic sites. Although removal of serotonergic and noradrenergic input did not alter hippocampal choline uptake relative to the contralateral control side, dopaminergic input reduction produced a significant elevation. After administration of delta 9-THC (20 mg/kg), reduction of choline uptake into lesioned hippocampi was not significantly different from that for the controls. These results indicate that monoaminergic afferents do not play a major role in the effect of delta 9-THC on cholinergic activity in the rat hippocampus.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6268755

Citation

Lindamood, C, and B K. Colasanti. "Involvement of Brain Monoamines in the Delta-9-tetrahydrocannabinol-induced Reduction of Hippocampal Choline Uptake." Journal of Neurochemistry, vol. 37, no. 3, 1981, pp. 788-91.
Lindamood C, Colasanti BK. Involvement of brain monoamines in the delta-9-tetrahydrocannabinol-induced reduction of hippocampal choline uptake. J Neurochem. 1981;37(3):788-91.
Lindamood, C., & Colasanti, B. K. (1981). Involvement of brain monoamines in the delta-9-tetrahydrocannabinol-induced reduction of hippocampal choline uptake. Journal of Neurochemistry, 37(3), 788-91.
Lindamood C, Colasanti BK. Involvement of Brain Monoamines in the Delta-9-tetrahydrocannabinol-induced Reduction of Hippocampal Choline Uptake. J Neurochem. 1981;37(3):788-91. PubMed PMID: 6268755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of brain monoamines in the delta-9-tetrahydrocannabinol-induced reduction of hippocampal choline uptake. AU - Lindamood,C,3rd AU - Colasanti,B K, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - 788 EP - 91 JF - Journal of neurochemistry JO - J Neurochem VL - 37 IS - 3 N2 - The role of monoamines in the transsynaptic reduction of neuronal activity produced by delta 9-tetrahydrocannabinol (delta 9-THC) in the septal-hippocampal cholinergic pathway has been investigated. Serotonergic afferents were chemically lesioned by unilateral infusion of 5,7-dihydroxytryptamine. Noradrenergic and dopaminergic inputs were selectively deleted by unilateral infusion of 6-hydroxydopamine into appropriate anatomic sites. Although removal of serotonergic and noradrenergic input did not alter hippocampal choline uptake relative to the contralateral control side, dopaminergic input reduction produced a significant elevation. After administration of delta 9-THC (20 mg/kg), reduction of choline uptake into lesioned hippocampi was not significantly different from that for the controls. These results indicate that monoaminergic afferents do not play a major role in the effect of delta 9-THC on cholinergic activity in the rat hippocampus. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/6268755/Involvement_of_brain_monoamines_in_the_delta_9_tetrahydrocannabinol_induced_reduction_of_hippocampal_choline_uptake_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=1981&volume=37&issue=3&spage=788 DB - PRIME DP - Unbound Medicine ER -