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[Biochemical aspects of depression (author's transl)].
Sem Hop 1981 Apr 18-25; 57(15-16):745-50SH

Abstract

Alterations of brain monoamines in animals produced by antidepressant administration suggest that depression may involve these monoamine systems. In an attempt to examine these possibilities, investigations of central noradrenergic and serotoninergic metabolism in depressed patients were performed but at times these have failed to produce convincing results. The exact mechanism of action of antidepressants remains also unknown. Nevertheless recent findings show that chronic treatment induces changes in the sensitivity of the beta-noradrenergic and serotoninergic receptors closely correlated in time with clinical improvement and common to all types of antidepressant drugs. Tricyclic anti-depressants also act directly as antagonists on alpha-adrenergic, cholinergic and H1, and H2 histaminergic receptors and it has been assumed that these pharmacological properties account for the side-effects of these drugs. Recently, high affinity binding sites for 3H-imipramine were demonstrated, the significance of which is still unresolved.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

6269184

Citation

Duchemin, A M.. "[Biochemical Aspects of Depression (author's Transl)]." La Semaine Des Hopitaux : Organe Fonde Par l'Association D'enseignement Medical Des Hopitaux De Paris, vol. 57, no. 15-16, 1981, pp. 745-50.
Duchemin AM. [Biochemical aspects of depression (author's transl)]. Sem Hop. 1981;57(15-16):745-50.
Duchemin, A. M. (1981). [Biochemical aspects of depression (author's transl)]. La Semaine Des Hopitaux : Organe Fonde Par l'Association D'enseignement Medical Des Hopitaux De Paris, 57(15-16), pp. 745-50.
Duchemin AM. [Biochemical Aspects of Depression (author's Transl)]. Sem Hop. 1981;57(15-16):745-50. PubMed PMID: 6269184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Biochemical aspects of depression (author's transl)]. A1 - Duchemin,A M, PY - 1981/4/18/pubmed PY - 1981/4/18/medline PY - 1981/4/18/entrez SP - 745 EP - 50 JF - La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris JO - Sem Hop VL - 57 IS - 15-16 N2 - Alterations of brain monoamines in animals produced by antidepressant administration suggest that depression may involve these monoamine systems. In an attempt to examine these possibilities, investigations of central noradrenergic and serotoninergic metabolism in depressed patients were performed but at times these have failed to produce convincing results. The exact mechanism of action of antidepressants remains also unknown. Nevertheless recent findings show that chronic treatment induces changes in the sensitivity of the beta-noradrenergic and serotoninergic receptors closely correlated in time with clinical improvement and common to all types of antidepressant drugs. Tricyclic anti-depressants also act directly as antagonists on alpha-adrenergic, cholinergic and H1, and H2 histaminergic receptors and it has been assumed that these pharmacological properties account for the side-effects of these drugs. Recently, high affinity binding sites for 3H-imipramine were demonstrated, the significance of which is still unresolved. UR - https://www.unboundmedicine.com/medline/citation/6269184/[Biochemical_aspects_of_depression__author's_transl_]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -