[Megalocytic anemia of alcoholics and folic acid (author's transl)].Sem Hop. 1981 Sep 8-15; 57(29-32):1259-65.SH
Megalocytic anemia of alcoholics is due to the deficiency of folic acid: the proof is the serum hypofolemia. The mechanism is complex and due to : a dietary deficiency; a malabsorption; an insufficiency of conversion of polyglutamate to monoglutamate; a liver deficiency; a specific effect of alcohol on the folate absorption. Alcohol has a toxic effect on the marrow and inhibits the folic acid.