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Delta-9-tetrahydrocannabinol as an antiemetic.
Am J Hosp Pharm. 1981 May; 38(5):639-46.AJ

Abstract

The use of delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients undergoing cancer chemotherapy is reviewed. The pharmacokinetics of THC is discussed, and the agent's effects on the central nervous, cardiovascular, respiratory, gastrointestinal, immune, endocrine, and reproductive systems are presented. The toxicology, potential hazards, and adverse reactions of THC are reviewed. Also reviewed are studies of THC's use as an antiemetic. THC appears to be an effective antiemetic in cancer patients undergoing chemotherapy. The maximal antinauseant effects often correlate with the attainment of a "high". THC has been found consistently more effective than placebo and at least as effective as prochlorperazine. In phenothiazine-resistant patients, THC's effectiveness has exceeded that of the phenothiazines. Efficacy may depend on the chemotherapeutic agent causing emesis. Elderly patients do not tolerate the THC "high" well. Concurrent administration of phenothiazines with THC may block the "high" without reducing THC's antiemetic effectiveness. Because of variations in individual tolerance, absorption, and the form of chemotherapy, flexibility is necessary in establishing the correct dose of THC.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6269423

Citation

Anderson, P O., and G G. McGuire. "Delta-9-tetrahydrocannabinol as an Antiemetic." American Journal of Hospital Pharmacy, vol. 38, no. 5, 1981, pp. 639-46.
Anderson PO, McGuire GG. Delta-9-tetrahydrocannabinol as an antiemetic. Am J Hosp Pharm. 1981;38(5):639-46.
Anderson, P. O., & McGuire, G. G. (1981). Delta-9-tetrahydrocannabinol as an antiemetic. American Journal of Hospital Pharmacy, 38(5), 639-46.
Anderson PO, McGuire GG. Delta-9-tetrahydrocannabinol as an Antiemetic. Am J Hosp Pharm. 1981;38(5):639-46. PubMed PMID: 6269423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta-9-tetrahydrocannabinol as an antiemetic. AU - Anderson,P O, AU - McGuire,G G, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 639 EP - 46 JF - American journal of hospital pharmacy JO - Am J Hosp Pharm VL - 38 IS - 5 N2 - The use of delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients undergoing cancer chemotherapy is reviewed. The pharmacokinetics of THC is discussed, and the agent's effects on the central nervous, cardiovascular, respiratory, gastrointestinal, immune, endocrine, and reproductive systems are presented. The toxicology, potential hazards, and adverse reactions of THC are reviewed. Also reviewed are studies of THC's use as an antiemetic. THC appears to be an effective antiemetic in cancer patients undergoing chemotherapy. The maximal antinauseant effects often correlate with the attainment of a "high". THC has been found consistently more effective than placebo and at least as effective as prochlorperazine. In phenothiazine-resistant patients, THC's effectiveness has exceeded that of the phenothiazines. Efficacy may depend on the chemotherapeutic agent causing emesis. Elderly patients do not tolerate the THC "high" well. Concurrent administration of phenothiazines with THC may block the "high" without reducing THC's antiemetic effectiveness. Because of variations in individual tolerance, absorption, and the form of chemotherapy, flexibility is necessary in establishing the correct dose of THC. SN - 0002-9289 UR - https://www.unboundmedicine.com/medline/citation/6269423/Delta_9_tetrahydrocannabinol_as_an_antiemetic_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6269423 DB - PRIME DP - Unbound Medicine ER -